David Pépin

TL;DR: Long-term streamflow records are used on intermediate-sized rivers across the continental United States to show that dams have homogenized the flow regimes on third- through seventh-order rivers in 16 historically distinctive hydrologic regions over the course of the 20th century.

TL;DR: In this paper, a cohort study was conducted among pregnant women presenting for care at 3 tertiary care centers in Boston, Massachusetts, where women with reverse transcription-polymerase chain reaction (RT-PCR) results positive for SARS-CoV-2 were recruited from April 2 to June 13, 2020 and follow-up occurred through July 10, 2020.

TL;DR: Systems serology characterized the Fc-profile of influenza, pertussis, and SARS-CoV-2-specific antibodies transferred across the placenta to point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.

TL;DR: It is shown that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice, representing a unique mechanism of contraception that spares the pool of quiescent primordial follicles (ovarian reserve).

TL;DR: The results suggest that chemotherapeutics may be stimulative to cancer stem cells and that selective inhibition of these cells by treating with MIS or targeting LIN28 should be considered in the development of therapeutics.