P
Prerna Anand
Researcher at King George's Medical University
Publications - 3
Citations - 128
Prerna Anand is an academic researcher from King George's Medical University. The author has contributed to research in topics: Single-nucleotide polymorphism & Plasmodium falciparum. The author has an hindex of 3, co-authored 3 publications receiving 111 citations.
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Journal ArticleDOI
Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.
Swapnil Sinha,Tabish Qidwai,Kanika Kanchan,Prerna Anand,Ganga N Jha,Sudhanshu S. Pati,Sanjib Mohanty,Saroj K. Mishra,Prajesh K. Tyagi,Surya K. Sharma,Vimala Venkatesh,Saman Habib +11 more
TL;DR: Interestingly, a SNP of the PECAM1 gene (rs668, exon 3, C/G) with low minor allele frequency in populations of the endemic region compared to the non-endemic region exhibited differential association with disease in these regions; the G allele was a risk factor for malaria in the endemic area, but exhibited significant association with protection from disease in theNon- endemic region.
Journal ArticleDOI
CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.
Swapnil Sinha,Ganga N Jha,Prerna Anand,Tabish Qidwai,Sudhanshu S. Pati,Sanjib Mohanty,Saroj K. Mishra,Prajesh K. Tyagi,Surya K. Sharma,Vimala Venkatesh,Saman Habib +10 more
TL;DR: Absence of correlation between levels of tumor necrosis factor-alpha, interferon-gamma, and interleukin-6 with CR1 levels in patients with severe disease indicated that RBC CR1 Levels in individuals are not the major determinants of pro-inflammatory cytokine release during infection.
Journal ArticleDOI
Distinct cytokine profiles define clinical immune response to falciparum malaria in regions of high or low disease transmission.
Swapnil Sinha,Tabish Qidwai,Kanika Kanchan,Ganga N Jha,Prerna Anand,Sudhanshu S. Pati,Sanjib Mohanty,Saroj K. Mishra,Prajesh K. Tyagi,Surya K. Sharma,Shally Awasthi,Vimala Venkatesh,Saman Habib +12 more
TL;DR: Levels of pro- and anti-inflammatory cytokines and the relative balance between the Th1 and Th2 response, illustrates how populations residing in areas of varying disease endemicity may respond to P. falciparum-induced immune challenge.