Sudhanshu S. Pati

TL;DR: Association of specific TNF and FCGR2A SNPs with cytokine levels and disease severity/resistance was indicated in patients from areas with differential disease endemicity, emphasizing the need for addressing the contribution of human genetic factors in malaria in the context of disease epidemiology and population genetic substructure within India.

TL;DR: Mixed-agglutination assays confirm the presence of both variant-specific and partially cross-reactive antibodies in convalescent-phase sera from Rourkela and adultSera from San Dulakudar, suggesting that they have antibodies with wide recognition of diverse PfEMP-1.

TL;DR: The study demonstrates the presence of regions in the Indian subcontinent such as Sundargarh District where P. falciparum is the primary cause of malaria and where malaria transmission rates are comparable to those found in many parts of Africa.

TL;DR: Interestingly, a SNP of the PECAM1 gene (rs668, exon 3, C/G) with low minor allele frequency in populations of the endemic region compared to the non-endemic region exhibited differential association with disease in these regions; the G allele was a risk factor for malaria in the endemic area, but exhibited significant association with protection from disease in theNon- endemic region.

TL;DR: The role of corticosteroids, pentoxifylline, desferrioxamine, mannitol and newer agents in the treatment of cerebral malaria is discussed and there are a number of shortcomings in the clinical trials.