Swapnil Sinha

TL;DR: The Indian Genome Variation (IGV) consortium as discussed by the authors is the first large-scale comprehensive study of the structure of the Indian population with wide-reaching implications, which aims to provide data on validated SNPs and repeats, both novel and reported, along with gene duplications, in over a thousand genes, in 15,000 individuals drawn from Indian subpopulations.

TL;DR: Association of specific TNF and FCGR2A SNPs with cytokine levels and disease severity/resistance was indicated in patients from areas with differential disease endemicity, emphasizing the need for addressing the contribution of human genetic factors in malaria in the context of disease epidemiology and population genetic substructure within India.

TL;DR: Interestingly, a SNP of the PECAM1 gene (rs668, exon 3, C/G) with low minor allele frequency in populations of the endemic region compared to the non-endemic region exhibited differential association with disease in these regions; the G allele was a risk factor for malaria in the endemic area, but exhibited significant association with protection from disease in theNon- endemic region.

TL;DR: Absence of correlation between levels of tumor necrosis factor-alpha, interferon-gamma, and interleukin-6 with CR1 levels in patients with severe disease indicated that RBC CR1 Levels in individuals are not the major determinants of pro-inflammatory cytokine release during infection.