P
Purnima Rao-Melacini
Researcher at Population Health Research Institute
Publications - 34
Citations - 7026
Purnima Rao-Melacini is an academic researcher from Population Health Research Institute. The author has contributed to research in topics: Myocardial infarction & Stroke. The author has an hindex of 14, co-authored 29 publications receiving 5819 citations. Previous affiliations of Purnima Rao-Melacini include McMaster University.
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Journal ArticleDOI
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
Martin O'Donnell,Martin O'Donnell,Denis Xavier,Lisheng Liu,Hongye Zhang,Siu Lim Chin,Purnima Rao-Melacini,Sumathy Rangarajan,Shofiqul Islam,Prem Pais,Matthew J. McQueen,Charles Mondo,Albertino Damasceno,Patricio Lopez-Jaramillo,Graeme J. Hankey,Antonio L. Dans,Khalid Yusoff,Thomas Truelsen,Hans-Christoph Diener,Ralph L. Sacco,Danuta Ryglewicz,Anna Członkowska,Christian Weimar,Xingyu Wang,Salim Yusuf +24 more
TL;DR: The findings suggest that ten risk factors are associated with 90% of the risk of stroke, and targeted interventions that reduce blood pressure and smoking, and promote physical activity and a healthy diet, could substantially reduce the burden of stroke.
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Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study
Martin O'Donnell,Martin O'Donnell,Siu Lim Chin,Sumathy Rangarajan,Denis Xavier,Lisheng Liu,Hongye Zhang,Purnima Rao-Melacini,Xiaohe Zhang,Prem Pais,Steven Agapay,Patricio Lopez-Jaramillo,Albertino Damasceno,Peter Langhorne,Matthew J. McQueen,Annika Rosengren,Mahshid Dehghan,Graeme J. Hankey,Antonio L. Dans,Ahmed Elsayed,Alvaro Avezum,Charles Mondo,Hans-Christoph Diener,Danuta Ryglewicz,Anna Członkowska,Nana Pogosova,Christian Weimar,Romaina Iqbal,Rafael Diaz,Khalid Yusoff,Khalid Yusoff,Afzalhussein Yusufali,Aytekin Oguz,Xingyu Wang,Ernesto Peñaherrera,Fernando Lanas,Okechukwu S Ogah,Adesola Ogunniyi,Helle K. Iversen,Germán Málaga,Zvonko Rumboldt,Shahram Oveisgharan,Fawaz Al Hussain,Daliwonga Magazi,Yongchai Nilanont,John Ferguson,Guillaume Paré,Salim Yusuf +47 more
TL;DR: The importance of potentially modifiable risk factors for stroke in different regions of the world, and in key populations and primary pathological subtypes of stroke, was quantified.
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Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
Carlos A. Morillo,José Antonio Marin-Neto,Alvaro Avezum,Sergio Sosa-Estani,Anis Rassi,Fernando Rosas,Erick Villena,Roberto Quiroz,Rina Bonilla,Constança Britto,Felipe Guhl,Elsa F. Velazquez,Laura R. Bonilla,Brandi Meeks,Purnima Rao-Melacini,Janice Pogue,A.C. Mattos,Janis Lazdins,Stuart J. Connolly,Salim Yusuf +19 more
TL;DR: Trypanocidal therapy with benznidazole in patients with established Chagas' cardiomyopathy significantly reduced serum parasite detection but did not significantly reduce cardiac clinical deterioration through 5 years of follow-up.
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Association of Diet, Exercise, and Smoking Modification With Risk of Early Cardiovascular Events After Acute Coronary Syndromes
TL;DR: Adherence to behavioral advice (diet, exercise, and smoking cessation) after acute coronary syndrome was associated with a substantially lower risk of recurrent cardiovascular events and suggest that behavioral modification should be given priority similar to other preventive medications immediately after acuteocardial infarction.
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Characteristics and Short-Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery: A Cohort Study
Philip J. Devereaux,Denis Xavier,Janice Pogue,Gordon H. Guyatt,Alben Sigamani,Ignacio Garutti,Kate Leslie,Purnima Rao-Melacini,Sue Chrolavicius,Homer Yang,Colin MacDonald,Alvaro Avezum,Luc Lanthier,Weijiang Hu,Salim Yusuf +14 more
TL;DR: Routine monitoring of troponin levels in at-risk patients is needed after surgery to detect most MIs, which have an equally poor prognosis regardless of whether they are symptomatic or asymptomatic.