Institution
University of La Frontera
Education•Temuco, Chile•
About: University of La Frontera is a education organization based out in Temuco, Chile. It is known for research contribution in the topics: Population & Sperm. The organization has 4483 authors who have published 7363 publications receiving 108060 citations. The organization is also known as: University of the Frontier.
Topics: Population, Sperm, Context (language use), Medicine, Cancer
Papers published on a yearly basis
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Johns Hopkins University1, Johns Hopkins University School of Medicine2, University of Toronto3, University of La Frontera4, Imperial College London5, Post Graduate Institute of Medical Education and Research6, Armed Forces Medical College7, National Institute of Mental Health and Neurosciences8, Hong Kong University of Science and Technology9, University of Maryland, Baltimore10
TL;DR: A draft map of the human proteome is presented using high-resolution Fourier-transform mass spectrometry to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-c coding RNAs and upstream open reading frames.
Abstract: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.
1,965 citations
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Population Health Research Institute1, Centra2, Charles University in Prague3, University of Washington Medical Center4, Brigham and Women's Hospital5, National University of Ireland, Galway6, University College London7, Jagiellonian University8, University of Würzburg9, Semmelweis University10, Karolinska Institutet11, University of the Philippines12, University of La Frontera13, University of Cape Town14, Aalborg University15, Katholieke Universiteit Leuven16, Catholic University of Korea17, Monash University18, Universiti Teknologi MARA19, Paris Diderot University20
TL;DR: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assign to aspirin alone.
Abstract: BackgroundWe evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. MethodsIn this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. ResultsThe primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1....
1,587 citations
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Population Health Research Institute1, The George Institute for Global Health2, University of Isfahan3, College of Health Sciences, Bahrain4, Aga Khan University5, University of La Frontera6, Cardiovascular Institute of the South7, Université de Sherbrooke8, Peking Union Medical College9, University of the Western Cape10, University of Gothenburg11, Wrocław Medical University12, University of Ottawa13, Independent University, Bangladesh14, Dubai Health Authority15, University of London16, St. John's University17
TL;DR: The findings suggest substantial room for improvement in hypertension diagnosis and treatment and suggest low education was associated with lower rates of awareness, treatment, and control in LICs, but not in other countries.
Abstract: Importance Hypertension is the most important preventable cause of morbidity and mortality globally, yet there are relatively few data collected using standardized methods. Objective To examine hypertension prevalence, awareness, treatment, and control in participants at baseline in the Prospective Urban Rural Epidemiology (PURE) study. Design, Setting, and Participants A cross-sectional study of 153 996 adults (complete data for this analysis on 142 042) aged 35 to 70 years, recruited between January 2003 and December 2009. Participants were from 628 communities in 3 high-income countries (HIC), 10 upper–middle-income and low–middle-income countries (UMIC and LMIC), and 4 low-income countries (LIC). Main Outcomes and Measures Hypertension was defined as individuals with self-reported treated hypertension or with an average of 2 blood pressure measurements of at least 140/90 mm Hg using an automated digital device. Awareness was based on self-reports, treatment was based on the regular use of blood pressure–lowering medications, and control was defined as individuals with blood pressure lower than 140/90 mm Hg. Results Among the 142 042 participants, 57 840 (40.8%; 95% CI, 40.5%-41.0%) had hypertension and 26 877 (46.5%; 95% CI, 46.1%-46.9%) were aware of the diagnosis. Of those who were aware of the diagnosis, the majority (23 510 [87.5%; 95% CI, 87.1%-87.9%] of those who were aware) were receiving pharmacological treatments, but only a minority of those receiving treatment were controlled (7634 [32.5%; 95% CI, 31.9%-33.1%]). Overall, 30.8%, 95% CI, 30.2%-31.4% of treated patients were taking 2 or more types of blood pressure–lowering medications. The percentages aware (49.0% [95% CI, 47.8%-50.3%] in HICs, 52.5% [95% CI, 51.8%-53.2%] in UMICs, 43.6% [95% CI, 42.9%-44.2%] in LMICs, and 40.8% [95% CI, 39.9%-41.8%] in LICs) and treated (46.7% [95% CI, 45.5%-47.9%] in HICs, 48.3%, [95% CI, 47.6%-49.1%] in UMICs, 36.9%, [95% CI, 36.3%-37.6%] in LMICs, and 31.7% [95% CI, 30.8%-32.6%] in LICs) were lower in LICs compared with all other countries for awareness (P Conclusions and Relevance Among a multinational study population, 46.5% of participants with hypertension were aware of the diagnosis, with blood pressure control among 32.5% of those being treated. These findings suggest substantial room for improvement in hypertension diagnosis and treatment.
1,432 citations
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National University of Ireland, Galway1, Population Health Research Institute2, St. John's Medical College3, Eduardo Mondlane University4, Glasgow Royal Infirmary5, Sahlgrenska University Hospital6, University of Western Australia7, University of the Philippines8, Mulago Hospital9, University Hospital Bonn10, Aga Khan University11, UCSI University12, Universiti Teknologi MARA13, Dubai Health Authority14, Istanbul Medeniyet University15, University of La Frontera16, University College Hospital, Ibadan17, University of Copenhagen18, Cayetano Heredia University19, University of Split20, Rush University Medical Center21, King Saud University22, University of Limpopo23, Mahidol University24
TL;DR: The importance of potentially modifiable risk factors for stroke in different regions of the world, and in key populations and primary pathological subtypes of stroke, was quantified.
1,313 citations
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Hamilton Health Sciences1, Population Health Research Institute2, University of São Paulo3, University of La Frontera4, Dubai Health Authority5, University of Gothenburg6, Isfahan University of Medical Sciences7, Independence University8, St. John's Medical College9, Aga Khan University10, Simon Fraser University11, Istanbul Medeniyet University12, UCSI University13, Universiti Teknologi MARA14, University of Wrocław15, University of Zimbabwe16, University of the Western Cape17, Peking Union Medical College18
TL;DR: This study suggests that measurement of grip strength is a simple, inexpensive risk-stratifying method for all-cause death, cardiovascular death, and cardiovascular disease.
1,184 citations
Authors
Showing all 4532 results
Name | H-index | Papers | Citations |
---|---|---|---|
Adi F. Gazdar | 157 | 776 | 104116 |
Alvaro Avezum | 93 | 279 | 48888 |
Yakov Kuzyakov | 87 | 667 | 37050 |
Patricio Lopez-Jaramillo | 66 | 357 | 24077 |
Gumersindo Feijoo | 66 | 333 | 12411 |
António Ferreira | 63 | 458 | 13726 |
Raúl Muñoz | 58 | 270 | 11286 |
Juan Carlos Roa | 56 | 257 | 12111 |
Rodrigo Vargas | 49 | 183 | 10924 |
Fernando Lanas | 48 | 203 | 23047 |
Luis Grande | 47 | 259 | 7431 |
María de la Luz Mora | 47 | 191 | 7588 |
Carlos Alberto Mandarim-de-Lacerda | 41 | 309 | 6661 |
Ricardo U. Sorensen | 40 | 151 | 9370 |
Adrian Baranchuk | 38 | 656 | 7508 |