Q
Qian Xu
Researcher at Johns Hopkins University School of Medicine
Publications - 20
Citations - 822
Qian Xu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Dorsal root ganglion & Neuropathic pain. The author has an hindex of 14, co-authored 18 publications receiving 619 citations. Previous affiliations of Qian Xu include Howard Hughes Medical Institute & Nanjing University.
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Journal ArticleDOI
Conventional and Kilohertz-frequency Spinal Cord Stimulation Produces Intensity- and Frequency-dependent Inhibition of Mechanical Hypersensitivity in a Rat Model of Neuropathic Pain
Ronen Shechter,Fei Yang,Qian Xu,Yong Kwan Cheong,Shao Qiu He,Andrei D. Sdrulla,Alene F. Carteret,Paul W. Wacnik,Xinzhong Dong,Richard A. Meyer,Srinivasa N. Raja,Yun Guan +11 more
TL;DR: Kilohertz SCS attenuated mechanical hypersensitivity in a time course and amplitude that differed from conventional 50 Hz SCS, and may involve different peripheral and spinal segmental mechanisms.
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Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord
TL;DR: This work identifies a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons, and proposes a "leaky gate" model in which Grp+ neurons transmit both itch and weak pain signals.
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Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain.
Zhe Li,Pang-Yen Tseng,Vinod Tiwari,Qian Xu,Shao Qiu He,Yan Wang,Qin Zheng,Liang Han,Zhiping Wu,Anna L. Blobaum,Yiyuan Cui,Vineeta Tiwari,Shuohao Sun,Yingying Cheng,Julie H.Y. Huang-Lionnet,Yixun Geng,Bo Xiao,Junmin Peng,Corey R. Hopkins,Srinivasa N. Raja,Yun Guan,Xinzhong Dong +21 more
TL;DR: The studies suggest that both agonists and positive allosteric modulators of MRG PRX1 may be promising novel drug candidates for managing persistent pain conditions and that activating MRGPRX1 is an effective way to treat persistent pain.
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Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model.
TL;DR: It is reported that A‐type K+ channels in dorsal root ganglion (DRG) are involved in the neuropathy of rat bone cancer pain and are a new target for diclofenac, a nonsteroidal anti‐inflammatory drug that can be used for therapy for this distinct pain.
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Electrical stimulation of low-threshold afferent fibers induces a prolonged synaptic depression in lamina II dorsal horn neurons to high-threshold afferent inputs in mice.
Andrei D. Sdrulla,Qian Xu,Shao Qiu He,Vinod Tiwari,Fei Yang,Chen Zhang,Chen Zhang,Bin Shu,Ronen Shechter,Srinivasa N. Raja,Yun Wang,Xinzhong Dong,Yun Guan +12 more
TL;DR: Findings show that activities in A&bgr;-fibers lead to frequency-dependent depression of synaptic transmission in SG neurons in response to peripheral noxious inputs, which is similar to that experienced by naive mice after SNL.