Qiang Xia

TL;DR: The results have characterized the m6A-mRNA landscape in human HCC and revealed YTHDF2 as a molecular ‘rheostat’ in epitranscriptome and cancer progression.

TL;DR: It is found that miR-199a-5p levels were significantly reduced in HCC patients treated with cisplatin-based chemotherapy, thus offering a new target for chemotherapy of HCC.

TL;DR: Recent advances in the function and principal mechanisms by regulating Nrf2 in liver diseases, including acute liver failure, hepatic ischemia–reperfusion injury (IRI), alcoholic liver disease, viral hepatitis, non-alcoholic fatty liver disease (NAFLD), non- alcoholic steatohepatitis (NASH), and hepatocellular carcinoma are discussed.

TL;DR: A novel function of LOXL4 in tumor metastasis mediated by exosomes through regulation of the FAK/Src pathway and angiogenesis in HCC is demonstrated.

TL;DR: It is demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance, thus offering a new target for chemotherapy of HCC.