Qing Bao

TL;DR: The current study showed that the NLRP3 inflammasome signaling axis could functionally mediate hRV-induced inflammation, pyroptosis, and mucus production in airway epithelium, which might be an essential mechanism associated with hRv-induced airway remodeling.

TL;DR: In this article, the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1β secretion and pyroptosis.

TL;DR: A functional association of IL-17 + T cells with neutrophils in CRSwNP is determined, and it is revealed that polyp microenvironment could promote IL- 17 + T cell differentiation, suggesting a potential feedback role for IL-16 + Tcell development and local neutrophilic inflammation.

TL;DR: PFOS and PFOA aggravated inflammation among OVA-induced asthmatic mice, by promoting the Th2 response in lymphocytes and disturbing the balance of Th1/Th2 through the JAK-STAT signaling pathway.

TL;DR: This study revealed that type 2 and type 17 iNKT cells were involved in eosinophilic and neutrophilic inflammation, respectively, in CRSwNP, while different inflammatory microenvironments could modulate the functions of iN KT cells, suggesting a role of i NKT cells in feedback mechanisms and local inflammation.