Q
Qingfei Wang
Researcher at University of Notre Dame
Publications - 17
Citations - 442
Qingfei Wang is an academic researcher from University of Notre Dame. The author has contributed to research in topics: Immune system & Immune checkpoint. The author has an hindex of 6, co-authored 16 publications receiving 155 citations.
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Proceedings ArticleDOI
A Poisson-Gaussian Denoising Dataset With Real Fluorescence Microscopy Images
Yide Zhang,Yinhao Zhu,Evan L. Nichols,Qingfei Wang,Siyuan Zhang,Cody J. Smith,Scott S. Howard +6 more
TL;DR: This paper constructs a dataset - the Fluorescence Microscopy Denoising (FMD) dataset - that is dedicated to Poisson-Gaussian denoising and uses this dataset to benchmark 10 representative denoised algorithms and finds that deep learning methods have the best performance.
Journal ArticleDOI
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.
Deanna N. Edwards,Verra M. Ngwa,Ariel L. Raybuck,Shan Wang,Yoonha Hwang,Laura C. Kim,Sung Hoon Cho,Yeeun Paik,Qingfei Wang,Siyuan Zhang,H. Charles Manning,Jeffrey C. Rathmell,Jeffrey C. Rathmell,Rebecca S. Cook,Rebecca S. Cook,Mark Boothby,Jin Chen +16 more
TL;DR: A "glutamine steal" scenario, in which cancer cells deprive tumor-infiltrating lymphocytes of needed glutamine, thus impairing anti-tumor immune responses is proposed, and tumor-selective targeting of glutamine metabolism may be a promising therapeutic strategy in TNBC.
Journal ArticleDOI
Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer.
Qingfei Wang,Ian H. Guldner,Samantha M. Golomb,Longhua Sun,Jack A. Harris,Xin Lu,Xin Lu,Siyuan Zhang,Siyuan Zhang +8 more
TL;DR: This study demonstrates a translational framework for treating rapidly evolving tumors through preclinical modeling and single-cell analyses and demonstrates that combination of IMC-targeting tyrosine kinase inhibitor cabozantinib and immune checkpoint blockade enhances anti-tumor immunity, and overcomes resistance.
Journal ArticleDOI
CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10
Ian H. Guldner,Qingfei Wang,Lin Yang,Samantha M. Golomb,Zhuo Zhao,Jacqueline Lopez,Abigail Brunory,Erin N. Howe,Yizhe Zhang,Bhavana Palakurthi,Martin Barron,Hongyu Gao,Hongyu Gao,Xiaoling Xuei,Xiaoling Xuei,Yunlong Liu,Yunlong Liu,Jun Li,Danny Z. Chen,Gary E. Landreth,Siyuan Zhang,Siyuan Zhang +21 more
TL;DR: The results demonstrate that loss of Cx3cr1 in CNS-myeloid triggers a Cxcl10-mediated vicious cycle, cultivating a br-met-promoting, immune-suppressive niche.
Journal ArticleDOI
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis.
Samantha M. Golomb,Ian H. Guldner,Anqi Zhao,Qingfei Wang,Bhavana Palakurthi,Emilija A. Aleksandrovic,Jacqueline Lopez,Shaun W. Lee,Kai Yang,Siyuan Zhang,Siyuan Zhang +10 more
TL;DR: Systemic changes due to aging and gut Dysbiosis increase propensity for neuroinflammation, providing insights into gut dysbiosis in age-related neurological diseases.