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Qiuhua Yang
Researcher at Georgia Regents University
Publications - 27
Citations - 664
Qiuhua Yang is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Medicine & Inflammation. The author has an hindex of 10, co-authored 17 publications receiving 337 citations. Previous affiliations of Qiuhua Yang include Peking University.
Papers
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Journal ArticleDOI
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.
Yapeng Cao,Xiaoyu Zhang,Xiaoyu Zhang,Lina Wang,Lina Wang,Qiuhua Yang,Qiuhua Yang,Qian Ma,Qian Ma,Jiean Xu,Jiean Xu,Jingjing Wang,Laszlo Kovacs,Ramon J. Ayon,Zhiping Liu,Zhiping Liu,Min Zhang,Yaqi Zhou,Xianqiu Zeng,Yiming Xu,Yong Wang,Yong Wang,David J. Fulton,Neal L. Weintraub,Rudolf Lucas,Zheng Dong,Jason X.-J. Yuan,Jennifer C. Sullivan,Louise Meadows,Scott A. Barman,Chaodong Wu,Junmin Quan,Mei Hong,Yunchao Su,Yuqing Huo +34 more
TL;DR: In this article, the authors investigated whether glycolytic regulator 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3)-mediated endothelial gly colysis plays a critical role in the development of pulmonary hypertension.
Journal ArticleDOI
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis
Zhiping Liu,Zhiping Liu,Siyuan Yan,Siyuan Yan,Jiaojiao Wang,Jiaojiao Wang,Yiming Xu,Yong Wang,Shuya Zhang,Xizhen Xu,Qiuhua Yang,Qiuhua Yang,Xianqiu Zeng,Xianqiu Zeng,Yaqi Zhou,Yaqi Zhou,Xuejiao Gu,Sarah Lu,Zhongjie Fu,David J. Fulton,Neal L. Weintraub,Ruth B. Caldwell,Wenbo Zhang,Chaodong Wu,Xiaoling Liu,Jiang-Fan Chen,Jiang-Fan Chen,Aftab Ahmad,Ismail Kaddour-Djebbar,Mohamed Al-Shabrawey,Qinkai Li,Xuejun Jiang,Ye Sun,Akrit Sodhi,Lois E.H. Smith,Mei Hong,Yuqing Huo +36 more
TL;DR: It is shown that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1α pathway, thereby suggesting new therapeutic targets for disease treatment.
Journal ArticleDOI
PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.
Qiuhua Yang,Qiuhua Yang,Jiean Xu,Jiean Xu,Qian Ma,Qian Ma,Zhiping Liu,Zhiping Liu,Varadarajan Sudhahar,Yapeng Cao,Yapeng Cao,Lina Wang,Lina Wang,Xianqiu Zeng,Xianqiu Zeng,Yaqi Zhou,Yaqi Zhou,Zhang Min,Yiming Xu,Yiming Xu,Yong Wang,Yong Wang,Neal L. Weintraub,Chunxiang Zhang,Tohru Fukai,Chaodong Wu,Lei Huang,Zhen Han,Tao Wang,David J. Fulton,Mei Hong,Yuqing Huo +31 more
TL;DR: It is shown that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of protein kinase AMP-activated (PRKA)/AMP-activated protein kinases (AMPKs) and this suggests that increased glycolysis in the endothelium of atheroprone arteries is a protective mechanism.
Journal ArticleDOI
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
Yiming Xu,Yiming Xu,Yong Wang,Yong Wang,Siyuan Yan,Siyuan Yan,Qiuhua Yang,Qiuhua Yang,Yaqi Zhou,Yaqi Zhou,Xianqiu Zeng,Xianqiu Zeng,Zhiping Liu,Zhiping Liu,Xiaofei An,Haroldo A. Toque,Zheng Dong,Xuejun Jiang,David J. Fulton,Neal L. Weintraub,Qinkai Li,Zsolt Bagi,Mei Hong,Detlev Boison,Chaodong Wu,Yuqing Huo,Yuqing Huo +26 more
TL;DR: Pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.
Journal ArticleDOI
Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis
Yiming Xu,Yiming Xu,Yong Wang,Yong Wang,Siyuan Yan,Siyuan Yan,Yaqi Zhou,Yaqi Zhou,Qiuhua Yang,Qiuhua Yang,Yue Pan,Xianqiu Zeng,Xianqiu Zeng,Xiaofei An,Zhiping Liu,Lina Wang,Lina Wang,Jiean Xu,Jiean Xu,Yapeng Cao,Yapeng Cao,David J. Fulton,Neal L. Weintraub,Zsolt Bagi,Nasrul Hoda,Xiaoling Wang,Qinkai Li,Mei Hong,Xuejun Jiang,Detlev Boison,Christian Weber,Chaodong Wu,Yuqing Huo +32 more
TL;DR: It is proposed that ADK downregulation‐induced elevation of intracellular adenosine levels in endothelial cells in the setting of hypoxia is one of the crucial intrinsic mechanisms that promote angiogenesis.