R
Rudolf Lucas
Researcher at Georgia Regents University
Publications - 165
Citations - 5725
Rudolf Lucas is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Tumor necrosis factor alpha & Lung injury. The author has an hindex of 39, co-authored 153 publications receiving 5036 citations. Previous affiliations of Rudolf Lucas include Weizmann Institute of Science & Innogenetics.
Papers
More filters
Journal Article
Cytokine production after intravenous or peritoneal gram-negative bacterial challenge in mice. Comparative protective efficacy of antibodies to tumor necrosis factor-alpha and to lipopolysaccharide.
Giorgio Zanetti,Didier Heumann,Jean Gérain,Josiane Kohler,Philippe Abbet,Catherine Barras,Rudolf Lucas,Michel P. Glauser,Jean Daniel Baumgartner +8 more
TL;DR: The striking differences between cytokine profiles as well as the divergent efficacy of anti-TNF-alpha antibody after i.p.v. challenges suggest that TNF- alpha may not be as important in the pathogenesis of lethal peritonitis than after lethal acute bacteremia.
Journal ArticleDOI
Multiple Forms of Angiostatin Induce Apoptosis in Endothelial Cells
Rudolf Lucas,L. Holmgren,Irène Garcia,Benilde Jiménez,Stefano J. Mandriota,F. Borlat,B. K. Sim,Zi Hao Wu,Georges E. Grau,Yuen Shing,Gerald A. Soff,Noel P. Bouck,Michael S. Pepper +12 more
TL;DR: In vitro findings point to endothelial cell apoptosis as a mechanism for the antiangiogenic effect of angiostatin in vivo.
Journal ArticleDOI
Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer
Gregor Fürstenberger,R. von Moos,Rudolf Lucas,Beat Thürlimann,H.-J. Senn,Juerg Hamacher,Eva-Maria Boneberg +6 more
TL;DR: The data suggest that chemotherapy can only reduce the amounts of mature CEC, probably reflecting detached cells from tumour vessels, whereas the EPC and their progenitors are mobilised by chemotherapy.
Journal ArticleDOI
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury
TL;DR: An overview of recently identified substances that inhibit and/or reverse endothelial barrier disruption and permeability or alveolar epithelial dysfunction is presented, which could contribute to the development of novel therapeutic strategies to combat permeability edema.
Journal ArticleDOI
Mapping the lectin-like activity of tumor necrosis factor.
Rudolf Lucas,Stefan Magez,R. J. De Leys,Lucie Fransen,JP Scheerlinck,M Rampelberg,Erwin Sablon,P. De Baetselier +7 more
TL;DR: Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian trypanosomes, probably with lectin-like affinity, which is functionally and spatially distinct from the mammalian TNF receptor binding sites.