Q
Quan M. Nhu
Researcher at University of Maryland, Baltimore
Publications - 14
Citations - 654
Quan M. Nhu is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 8 publications receiving 561 citations.
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Journal ArticleDOI
Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo
Quan M. Nhu,Kari Ann Shirey,John R. Teijaro,Donna L. Farber,Sarah Netzel-Arnett,Toni M. Antalis,Alessio Fasano,Stefanie N. Vogel +7 more
TL;DR: In this article, the functional and physical interactions between TLR4 and PAR(2) were investigated in mucosal epithelial cells (ECs) and showed that activation of PAR negatively regulated TLR3-dependent antiviral pathway, blunting the expression of ILR3/interferon regulatory factor-3 (IRF-3)-driven genes.
Journal ArticleDOI
Analysis of Proteinase-activated Receptor 2 and TLR4 Signal Transduction A NOVEL PARADIGM FOR RECEPTOR COOPERATIVITY
Prasad Rallabhandi,Quan M. Nhu,Vladimir Y. Toshchakov,Wenji Piao,Andrei E. Medvedev,Morley D. Hollenberg,Alessio Fasano,Stefanie N. Vogel +7 more
TL;DR: The data suggest a unique interaction between two distinct innate immune response receptors and support a novel paradigm of receptor cooperativity in inflammatory responses.
Analysis of Proteinase-activated Receptor 2 and TLR4
Prasad Rallabhandi,Quan M. Nhu,Vladimir Y. Toshchakov,Wenji Piao,Andrei E. Medvedev,Morley D. Hollenberg,Alessio Fasano,Stefanie N. Vogel +7 more
TL;DR: In this paper, proteinase-activated receptor 2 (PAR2) is activated at inflammatory sites by proteolytic cleavage of its extracellular N terminus by trypsin-like enzymes, exposing a tethered, receptor-activating ligand.
Journal ArticleDOI
Transcriptional regulation of lipopolysaccharide (LPS)-induced Toll-like receptor (TLR) expression in murine macrophages: role of interferon regulatory factors 1 (IRF-1) and 2 (IRF-2)
TL;DR: Findings suggest that the trans-acting factors, IRF-1 and IRf-2, contribute to the innate immune response to infections by regulating TLR gene expression.
Journal ArticleDOI
Sialyl Residues Modulate LPS-Mediated Signaling through the Toll-Like Receptor 4 Complex
Chiguang Feng,Nicholas M. Stamatos,Anatoliy I. Dragan,Andrei E. Medvedev,Melissa Whitford,Lei Zhang,Chang Song,Prasad Rallabhandi,Leah E. Cole,Quan M. Nhu,Stefanie N. Vogel,Chris D. Geddes,Alan S. Cross +12 more
TL;DR: Sialyl residues on TLR4 modulate LPS responsiveness, perhaps by facilitating clustering of the homodimers, and that sialic acid, and perhaps other glycosyl species, regulate MD2 activity required for LPS-mediated signaling is concluded.