Quinn P. Peterson

TL;DR: A scalable differentiation protocol is reported that can generate hundreds of millions of glucose-responsive β cells from hPSC in vitro that secrete human insulin into the serum of mice shortly after transplantation in a glucose-regulated manner, and transplantation of these cells ameliorates hyperglycemia in diabetic mice.

TL;DR: Chemical genetic analysis has uncovered unanticipated opposing roles of PI3K and ERK in artery/vein specification.

TL;DR: The discovery of a compound, PAC-1, which enhances procaspase-3 activity in vitro and induces apoptotic death in cancer cells in culture and in mouse xenograft models is reported, indicating this discovery of the in vitro mechanism of action ofPAC-1 is critical to the development and optimization of other procaspases-activating compounds.

TL;DR: The data presented herein further bolster the hypothesis that PAC-1 induces apoptosis in cancer cells through the direct activation of procaspase-3, has implications for the design and discovery of next-generation procaspases-3 activating compounds, and sheds light on the anti-apoptotic role of cellular zinc.

TL;DR: A transgenic zebrafish line that enables inducible expression of the human AML1-ETO oncogene is described, and it is demonstrated that scl is an important mediator of the ability of AML 1-ETo to reprogram hematopoietic cell fate decisions, suggesting that sCl may be an important contributor to AML-1- ETO-associated leukemia.