R
R Gendelman
Researcher at National Institutes of Health
Publications - 15
Citations - 2916
R Gendelman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Kaposi's sarcoma & Angiogenesis. The author has an hindex of 12, co-authored 15 publications receiving 2882 citations.
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Journal ArticleDOI
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation.
Barbara Ensoli,Luigi Buonaguro,Giovanni Barillari,Valeria Fiorelli,R Gendelman,Richard A. Morgan,Paul T. Wingfield,Robert C. Gallo +7 more
TL;DR: The data suggest that Tat can be released by a mechanism(s) other than cell death and that the cell growth-promoting activity and the virus-transactivating effect of extracellular Tat are mediated by different pathways.
Journal ArticleDOI
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
Barbara Ensoli,R Gendelman,Phillip D. Markham,Valeria Fiorelli,Sandra Colombini,Mark Raffeld,Aurelio Cafaro,Hsiao-Kuey Chang,John N. Brady,Robert C. Gallo +9 more
TL;DR: Basic fibroblast growth factor and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice, which may explain the higher frequency and aggressiveness of this form of KS.
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The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.
TL;DR: It is suggested that RGD-recognizing integrins mediate the vascular cell-growth-promoting effect of Tat, and immune stimulation (rather than immune deficiency) is a component of AIDS-KS pathogenesis.
Journal Article
Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.
Felipe Samaniego,Phillip D. Markham,R Gendelman,Yoshiki Watanabe,Vivien Kao,Kimberly Kowalski,Joseph A. Sonnabend,Aldo Pintus,Robert C. Gallo,Barbara Ensoli +9 more
TL;DR: Results indicate that inflammatory cytokines present in KS lesions stimulate the production of bFGF and VEGF, which, in turn, cooperate to induce angiogenesis, edema, and KS lesion formation.
Journal ArticleDOI
Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.
TL;DR: It is shown that KS spindle cells have features of activated endothelial cells, and that conditioned media from activated T cells, rich in the same inflammatory cytokines increased in HIV-1-infected individuals, induce normal endothelium cells to acquire the phenotypic and functional features of KS cells.