V
Valeria Fiorelli
Researcher at Istituto Superiore di Sanità
Publications - 44
Citations - 3634
Valeria Fiorelli is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 28, co-authored 44 publications receiving 3587 citations. Previous affiliations of Valeria Fiorelli include Sapienza University of Rome & National Institutes of Health.
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Journal ArticleDOI
Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation.
Barbara Ensoli,Luigi Buonaguro,Giovanni Barillari,Valeria Fiorelli,R Gendelman,Richard A. Morgan,Paul T. Wingfield,Robert C. Gallo +7 more
TL;DR: The data suggest that Tat can be released by a mechanism(s) other than cell death and that the cell growth-promoting activity and the virus-transactivating effect of extracellular Tat are mediated by different pathways.
Journal ArticleDOI
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
Barbara Ensoli,R Gendelman,Phillip D. Markham,Valeria Fiorelli,Sandra Colombini,Mark Raffeld,Aurelio Cafaro,Hsiao-Kuey Chang,John N. Brady,Robert C. Gallo +9 more
TL;DR: Basic fibroblast growth factor and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice, which may explain the higher frequency and aggressiveness of this form of KS.
Journal Article
Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. Implications for AIDS-Kaposi's sarcoma pathogenesis.
Giovanni Barillari,Luigi Buonaguro,Valeria Fiorelli,John Hoffman,Frank H. Michaels,Robert C. Gallo,Barbara Ensoli +6 more
TL;DR: It is reported that conditioned media from activated or dysregulated T cells contain a variety of cytokines that promote the growth of spindle cells derived from KS lesions of AIDS patients (AIDS-KS cells) and induce normal vascular cells, potential cell progenitors of the AIDS- KS cells, to acquire features of the KS cell phenotype.
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The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the α5β1 and αvβ3 integrins and by mobilizing sequestered basic fibroblast growth factor
Giovanni Barillari,Cecilia Sgadari,Valeria Fiorelli,Felipe Samaniego,Sandra Colombini,Vittorio Manzari,Andrea Modesti,B. C. Nair,Aurelio Cafaro,Michael Stürzl,Barbara Ensoli +10 more
TL;DR: The results shown herein indicate that two different Tat domains cooperate to induce these effects by different pathways, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules.
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Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.
TL;DR: It is shown that KS spindle cells have features of activated endothelial cells, and that conditioned media from activated T cells, rich in the same inflammatory cytokines increased in HIV-1-infected individuals, induce normal endothelium cells to acquire the phenotypic and functional features of KS cells.