Sandra Colombini

TL;DR: Basic fibroblast growth factor and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice, which may explain the higher frequency and aggressiveness of this form of KS.

TL;DR: The results indicate that PBMC that are polymerase chain reaction (PCR)-positive at day 0 generally loose the virus upon culture, and suggest that infected monocytes may carry the virus to tissues, transmit the infection, or differentiate in loco in spindle cells with endothelial macrophage markers.

TL;DR: Results presented here show that cells from all Japanese patients with adult T-cell leukaemia and several patients with various mature T- cell malignancies from elsewhere contained one or more copies of a highly conserved HTLV genome.

TL;DR: The results shown herein indicate that two different Tat domains cooperate to induce these effects by different pathways, suggesting that Tat enhances angiogenesis and promotes KS progression by a molecular mimicry of these molecules.

TL;DR: It is shown that both acquired immunodeficiency syndrome (AIDS)-KS and classical KS (C-KS) lesions are infiltrated by CD8+ T cells and CD14+/CD68+ monocytes-macrophages producing high levels of gamma-interferon (gamma IFN) which, in turn, promotes the formation of KS spindle cells with angiogenic phenotype.