Journal ArticleDOI
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
Barbara Ensoli,R Gendelman,Phillip D. Markham,Valeria Fiorelli,Sandra Colombini,Mark Raffeld,Aurelio Cafaro,Hsiao-Kuey Chang,John N. Brady,Robert C. Gallo +9 more
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TLDR
Basic fibroblast growth factor and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice, which may explain the higher frequency and aggressiveness of this form of KS.Abstract:
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.read more
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Oral and Maxillofacial Pathology
TL;DR: Forensic Dentistry Appendix: Differential Diagnosis of Oral and Maxillofacial Diseases.
Journal ArticleDOI
Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas
TL;DR: A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas.
Journal ArticleDOI
Fibroblast growth factor signalling: from development to cancer
Nicholas C. Turner,Richard Grose +1 more
TL;DR: There is now substantial evidence for the importance of FGF signalling in the pathogenesis of diverse tumour types, and clinical reagents that specifically target the FGFs or FGF receptors are being developed.
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Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease
Jean Soulier,Laurence Grollet,Eric Oksenhendler,Patrice Cacoub,Dominique Cazals-Hatem,Paul Babinet,Marie-Françoise D'Agay,Jean-Pierre Clauvel,Marline Raphael,Laurent Degos,François Sigaux +10 more
TL;DR: Data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients, which is a close association with Kaposi's sarcoma.
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Tyrosine kinase inhibition: an approach to drug development
Alexander Levitzki,Aviv Gazit +1 more
TL;DR: This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.
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