R. L. Chang

TL;DR: Four benzo-ring epoxides of the environmental carcinogen benzo(a)pyrene (BP) were tested for mutagenic and cytotoxic activity in 3 strains of Salmonella typhimurium and in Chinese hamster V79 cells.

TL;DR: BP 7,8-diol-9,10-epoxide was approximately 5, 10 and 40 times more mutagenic than benzo[a]pyrene 4,5-oxide (BP 4, 5-oxide) in strains TA 98 and TA 100 of S. typhimurium and in cultured Chinese hamster V79 cells.

TL;DR: Benzo(a)pyrene 4,5-oxide was the most mutagenic of the compounds tested in both the bacterial and mammalian systems and was extremely cytotoxic to the V79 cells but had no observable toxicity in the bacterial strains.

TL;DR: These results with known metabolites of the environmental carcinogen benzo[a]pyrene represent the first report of differences in mutagenic activity among optical enantiomers.

TL;DR: Treatment of preweanling mice with the above doses of the phenolic compounds 10 min before the i.p. injection of a total dose of 30 nmol of B[a]P 7,8-diol-9,10-epoxide-2 during the animal's first 15 days of life caused a 44-75% inhibition in the number of diol-EPoxide-induced pulmonary tumors per mouse.