R. Moll

TL;DR: During cell transformation and tumor devel- opment this cell type specificity of intermediate filaments is largely conserved’ and classification of tumors by their specific type of intermediate Filaments has re- cently become very valuable in clinical histodiagnosis.

TL;DR: Individual cytokeratins provide tissue- or cell type-specific markers that are useful in the definition and identification of the relatedness or the origin of epithelial and carcinoma cells.

TL;DR: Using cytoskeletal proteins from human biopsies and autopsies, the cytokeratin polypeptide patterns of diverse primary and metastatic carcinomas are examined and compared with those of corresponding normal epithelial tissues and cultured cells and the possibility of cell type heterogeneity within a given tumor is discussed.

TL;DR: The intermediate filament (IF) system of the various cells of human, pig and rat ovaries was studied by electron microscopy, by immunolocalization using antibodies to cytokeratins, vimentin, desmin and desmoplakin, and by two-dimensional gel electrophoresis of cytoskeletal proteins from microdissected tissue samples to indicate that three cell types of human ovary can be regarded as true epithelial cells which simultaneously express vimentsin.

TL;DR: It is concluded that synaptophysin is a significant as well as novel NE marker, and the use of antibody SY 38 as a broad range marker for the study and diagnosis of NE neoplasms is proposed.