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Rachel L Knowles
Researcher at UCL Institute of Child Health
Publications - 59
Citations - 1355
Rachel L Knowles is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Population & Newborn screening. The author has an hindex of 21, co-authored 54 publications receiving 1116 citations. Previous affiliations of Rachel L Knowles include Great Ormond Street Hospital & University of Toronto.
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Journal ArticleDOI
Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis.
Rachel L Knowles,Ingolf Griebsch,Carol Dezateux,Jackie Brown,Catherine Bull,Christopher Wren +5 more
TL;DR: Pulse oximetry is a promising alternative newborn screening strategy but further evaluation is needed to obtain more precise estimates of test performance and to inform optimal timing, diagnostic and management strategies.
Journal ArticleDOI
Sharing and reuse of individual participant data from clinical trials: principles and recommendations
Christian Ohmann,Rita Banzi,Steve Canham,Serena Battaglia,Mihaela Matei,Christopher Ariyo,Lauren B. Becnel,Barbara E. Bierer,Sarion R. Bowers,Luca Clivio,Monica Dias,Christiane Druml,Hélène Faure,Martin Fenner,Jose Galvez,Davina Ghersi,Christian Gluud,Trish Groves,Paul Houston,Ghassan Karam,Dipak Kalra,Rachel L Knowles,Karmela Krleža-Jerić,Christine Kubiak,Wolfgang Kuchinke,Rebecca Kush,Ari Lukkarinen,Pedro Silverio Marques,Andrew Newbigging,Jennifer O’Callaghan,Philippe Ravaud,Irene Schlünder,Daniel Shanahan,Helmut Sitter,Dylan Spalding,Catrin Tudur-Smith,Peter van Reusel,Evert-Ben van Veen,Gerben Rienk Visser,Julia Wilson,Jacques Demotes-Mainard +40 more
TL;DR: The adoption of the recommendations in this document would help to promote and support data sharing and reuse among researchers, adequately inform trial participants and protect their rights, and provide effective and efficient systems for preparing, storing and accessing data.
Journal ArticleDOI
Comparing the clinical and economic effects of clinical examination, pulse oximetry, and echocardiography in newborn screening for congenital heart defects: A probabilistic cost-effectiveness model and value of information analysis
Ingolf Griebsch,Rachel L Knowles,Jacqueline Brown,Catherine Bull,Christopher Wren,Carol Dezateux +5 more
TL;DR: Adding pulse oximetry to clinical examination is likely to be a cost-effective newborn screening strategy for CHD, but further research is required before this policy can be recommended.
Journal ArticleDOI
Patient-reported quality of life outcomes for children with serious congenital heart defects
TL;DR: Child self-report measures of QoL would be a valuable addition to clinical outcome audit in this age group and appear related to the burden of clinical intervention rather than underlying cardiac diagnosis.
Journal ArticleDOI
Prevalence of permanent childhood hearing loss detected at the universal newborn hearing screen: Systematic review and meta-analysis
E. Butcher,Carol Dezateux,Carol Dezateux,Mario Cortina-Borja,Rachel L Knowles,Rachel L Knowles +5 more
TL;DR: In VHD countries, 1 per 1000 screened newborns require referral to clinical services for PCHL, and prevalence is higher in those admitted to NICU.