Rachel Young

TL;DR: This new reference genome improves the contig N50 of the previous short-read based buffalo assembly more than a thousand-fold and contains only 383 gaps, which surpasses the human and goat references in sequence contiguity and facilitates the annotation of hard to assemble gene clusters such as the major histocompatibility complex (MHC).

TL;DR: This high-resolution gene expression atlas for sheep is the largest transcriptomic dataset from any livestock species to date and provides a resource to improve the annotation of the current reference genome for sheep, presenting a model transcriptome for ruminants and insight into gene, cell and tissue function at multiple developmental stages.

TL;DR: This review focuses on the potential of this latter technology to modify mammalian genomes without the need to apply challenging and less-efficient protocols and the complementary aims of these new approaches and the as-yet-unexplored possibilities offered by their combination.

TL;DR: It is demonstrated that ADGRE1 is a myeloid differentiation marker in pigs, absent from progenitors in bone marrow, highly-expressed in mature granulocytes, monocytes, and tissue macrophages and induced by macrophage colony-stimulating factor (CSF1) treatment in vivo.

TL;DR: It is reported that the Shadoo‐encoding gene knockdown in PrP‐knockout mouse embryos results in a lethal phenotype, occurring between E8 and E11, not observed on the wild‐type genetic background.