Wai Yee Low

TL;DR: It is demonstrated that improved continuity of assembled sequence warrants the adoption of ARS-UCD1.2 as the new cattle reference genome and that increased assembly accuracy will benefit future research on this species.

TL;DR: This new reference genome improves the contig N50 of the previous short-read based buffalo assembly more than a thousand-fold and contains only 383 gaps, which surpasses the human and goat references in sequence contiguity and facilitates the annotation of hard to assemble gene clusters such as the major histocompatibility complex (MHC).

TL;DR: It is proposed that the parallel evolution observed at this site is an adaptive response to an environmental toxin and that sequencing of historical alleles suggests that this toxin was not a synthetic insecticide.

TL;DR: A pipeline to produce haplotype-resolved, chromosome-level genomes of Angus and Brahman cattle breeds from a crossbred individual is described and comparisons of the two genomes are reported.

TL;DR: Two-dimensional crystallography and NMR experiments of GSTD1 indicate that conformational changes occur upon glutathione and DDT binding and the residues that broaden uponDDT binding support the predicted binding site.