R
Radoslav Aleksandrov
Researcher at Bulgarian Academy of Sciences
Publications - 9
Citations - 573
Radoslav Aleksandrov is an academic researcher from Bulgarian Academy of Sciences. The author has contributed to research in topics: DNA repair & DNA. The author has an hindex of 5, co-authored 8 publications receiving 313 citations. Previous affiliations of Radoslav Aleksandrov include Centre national de la recherche scientifique & Sofia University.
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Journal ArticleDOI
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Stephen J. Pettitt,Dragomir B. Krastev,Inger Brandsma,Amy Dréan,Feifei Song,Radoslav Aleksandrov,Maria I. Harrell,Malini Menon,Rachel Brough,James Campbell,Jessica Frankum,Michael Ranes,Helen Pemberton,Rumana Rafiq,Kerry Fenwick,Amanda Swain,Sebastian Guettler,Jung-Min Lee,Elizabeth M. Swisher,Stoyno S. Stoynov,Kosuke Yusa,Alan Ashworth,Christopher J. Lord +22 more
TL;DR: It is found that PARP1 mutations are tolerated in BRCA1 mutated cells, suggesting alternative resistance mechanisms and reinforces the importance of trappedPARP1 as a cytotoxic DNA lesion and suggests that PARp1 intramolecular interactions might influence PARPi-mediated cytotoxicity.
Posted ContentDOI
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Stephen J. Pettitt,Dragomir B. Krastev,Inger Brandsma,Amy Dréan,Feifei Song,Radoslav Aleksandrov,Maria I. Harrell,Malini Menon,Rachel Brough,James Campbell,Jessica Frankum,Michael Ranes,Helen Pemberton,Rumana Rafiq,Kerry Fenwick,Amanda Swain,Sebastian Guettler,Jung-Min Lee,Elizabeth M. Swisher,Stoyno S. Stoynov,Kosuke Yusa,Alan Ashworth,Christopher J. Lord +22 more
TL;DR: Genome-wide and high-density CRISPR-Cas9 “tag, mutate and enrich” mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance and suggest that interactions between non-DNA binding domains ofPARP1 influence cytotoxicity.
Journal ArticleDOI
Protein Dynamics in Complex DNA Lesions
Radoslav Aleksandrov,Anton Dotchev,Ina Poser,Dragomir B. Krastev,Georgi P. Georgiev,Greta Panova,Yordan Babukov,Georgi Danovski,Teodora Dyankova,Lars Hubatsch,Aneliya Ivanova,Aleksandar Atemin,Marina N. Nedelcheva-Veleva,Susanne Hasse,Mihail Sarov,Frank Buchholz,Anthony A. Hyman,Stephan W. Grill,Stoyno S. Stoynov +18 more
TL;DR: The systematic study of the dynamics of DNA repair proteins in complex DNA lesions reveals the multifaceted coordination between the repair pathways and provides a kinetics-based resource to study genomic instability and anticancer drug impact.
Journal ArticleDOI
The Chromatin Response to Double-Strand DNA Breaks and Their Repair.
TL;DR: Given the paramount importance of D SB repair in tumorigenesis and cancer progression, DSB repair has turned into an attractive target for the development of novel anticancer therapies, some of which have already entered the clinic.
Journal ArticleDOI
Recognition of Vipera ammodytes meridionalis neurotoxin vipoxin and its components using phage-displayed scFv and polyclonal antivenom sera
Vishnya Stoyanova,Radoslav Aleksandrov,Maria Lukarska,Deyan Duhalov,Vasil Atanasov,Svetla Petrova +5 more
TL;DR: Rec recombinant human scFv antibodies will be used for epitope mapping studies required to shed light on the role of the phospholipase A₂ activity for the vipoxin toxicity and its effective neutralization.