R
Rafal Bartoszewski
Researcher at Gdańsk Medical University
Publications - 79
Citations - 3634
Rafal Bartoszewski is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Unfolded protein response & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 28, co-authored 67 publications receiving 2603 citations. Previous affiliations of Rafal Bartoszewski include University of Alabama at Birmingham & University of Wrocław.
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Journal ArticleDOI
Comprehensive review of antimicrobial activities of plant flavonoids
TL;DR: The development and application of flavonoid-based drugs could be a promising approach for antibiotic-resistant infections and improve understanding of the biological and molecular roles of plant flavonoids, focusing mostly on their antimicrobial activities.
Journal ArticleDOI
Somatic mosaicism for copy number variation in differentiated human tissues.
Arkadiusz Piotrowski,Arkadiusz Piotrowski,Carl E.G. Bruder,Robin Andersson,Teresita Díaz de Ståhl,Uwe Menzel,Johanna Sandgren,Andrzej Poplawski,Desiree von Tell,Chiquito J. Crasto,Adam Bogdan,Rafal Bartoszewski,Zsuzsa Bebok,Maciej Krzyżanowski,Zbigniew Jankowski,E. Christopher Partridge,Jan Komorowski,Jan P. Dumanski,Jan P. Dumanski +18 more
TL;DR: The results indicate that humans are commonly affected by somatic mosaicism for stochastic CNVs, which occur in a substantial fraction of cells, and biobanks should consider sampling multiple tissues to better address mosaicism in the studies of somatic disorders.
Journal ArticleDOI
A Synonymous Single Nucleotide Polymorphism in ΔF508 CFTR Alters the Secondary Structure of the mRNA and the Expression of the Mutant Protein
Rafal Bartoszewski,Michael J. Jablonsky,Sylwia Bartoszewska,Lauren Stevenson,Qun Dai,John C. Kappes,James F. Collawn,Zsuzsa Bebok +7 more
TL;DR: It is proposed that mRNA “misfolding” contributes to ΔF508 CFTR protein misfolding and consequently to the severity of the human Δf508 phenotype.
Journal ArticleDOI
miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target.
Marcin Serocki,Sylwia Bartoszewska,Anna Janaszak-Jasiecka,Renata Ochocka,James F. Collawn,Rafal Bartoszewski +5 more
TL;DR: The significance of the microRNAs on the relationship between the HIFs under both physiological and pathophysiological conditions is reviewed and miRNAs that endogenously regulate gene expression via the RNA interference pathway are shown to play critical roles in the hypoxia response pathways.
A Synonymous Single Nucleotide Polymorphism in F508 CFTR Alters the Secondary Structure of the mRNA and the
Rafal Bartoszewski,Michael J. Jablonsky,Sylwia Bartoszewska,Lauren Stevenson,Qun Dai,John C. Kappes,James F. Collawn,Zsuzsa Bebok +7 more
TL;DR: The loss of phenylalanine at the 508 position of the CFTR protein (F508), a synonymous codon change for isoleucine 507(Ile507ATT), and proteinmisfolding as mentioned in this paper.