A
Arkadiusz Piotrowski
Researcher at Gdańsk Medical University
Publications - 69
Citations - 2829
Arkadiusz Piotrowski is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 27, co-authored 64 publications receiving 2511 citations. Previous affiliations of Arkadiusz Piotrowski include University of Alabama & University of Alabama at Birmingham.
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Journal ArticleDOI
Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation Profiles
Carl E.G. Bruder,Arkadiusz Piotrowski,Antoinet C.J. Gijsbers,Robin Andersson,Stephen W. Erickson,Teresita Díaz de Ståhl,Uwe Menzel,Johanna Sandgren,Desiree von Tell,Andrzej Poplawski,Michael J. Crowley,Chiquito J. Crasto,E. Christopher Partridge,Hemant K. Tiwari,David B. Allison,Jan Komorowski,Gert-Jan B. van Ommen,Dorret I. Boomsma,Nancy L. Pedersen,Johan T. den Dunnen,Karin Wirdefeldt,Jan P. Dumanski,Jan P. Dumanski +22 more
TL;DR: It is suggested that CNV analysis in phenotypically discordant monozygotic twins may provide a powerful tool for identifying disease-predisposition loci and that caution should be exercised when interpreting disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics.
Journal ArticleDOI
Somatic mosaicism for copy number variation in differentiated human tissues.
Arkadiusz Piotrowski,Arkadiusz Piotrowski,Carl E.G. Bruder,Robin Andersson,Teresita Díaz de Ståhl,Uwe Menzel,Johanna Sandgren,Andrzej Poplawski,Desiree von Tell,Chiquito J. Crasto,Adam Bogdan,Rafal Bartoszewski,Zsuzsa Bebok,Maciej Krzyżanowski,Zbigniew Jankowski,E. Christopher Partridge,Jan Komorowski,Jan P. Dumanski,Jan P. Dumanski +18 more
TL;DR: The results indicate that humans are commonly affected by somatic mosaicism for stochastic CNVs, which occur in a substantial fraction of cells, and biobanks should consider sampling multiple tissues to better address mosaicism in the studies of somatic disorders.
Journal ArticleDOI
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas
Arkadiusz Piotrowski,Arkadiusz Piotrowski,Jing Xie,Ying F Liu,Andrzej Poplawski,Alicia Gomes,Piotr Madanecki,Chuanhua Fu,Michael R. Crowley,David K. Crossman,Linlea Armstrong,Dusica Babovic-Vuksanovic,Amanda L. Bergner,Jaishri O. Blakeley,Andrea L Blumenthal,Molly S. Daniels,Howard Feit,Kathy Gardner,Stephanie Hurst,Christine Kobelka,Chung Lee,Rebecca Nagy,Katherine A. Rauen,John M. Slopis,Pim Suwannarat,Judith A. Westman,Andrea Zanko,Bruce R. Korf,Ludwine Messiaen +28 more
TL;DR: The findings identify LZTR1 as a gene predisposing to an autosomal dominant inherited disorder of multiple schwannomas in ∼80% of 22q-relatedSchwannomatosis cases lacking mutation in SMARCB1.
Journal ArticleDOI
Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells
Lars Forsberg,Chiara Rasi,Hamid Reza Razzaghian,Geeta Pakalapati,Lindsay L. Waite,Krista Stanton Thilbeault,Anna Ronowicz,Nathan E. Wineinger,Hemant K. Tiwari,Dorret I. Boomsma,Maxwell P. Westerman,Jennifer R. Harris,Robert Lyle,Magnus Essand,Fredrik Eriksson,Themistocles L. Assimes,Carlos Iribarren,Eric Strachan,Terrance P. O'Hanlon,Lisa G. Rider,Frederick W. Miller,Vilmantas Giedraitis,Lars Lannfelt,Martin Ingelsson,Arkadiusz Piotrowski,Nancy L. Pedersen,Devin Absher,Jan P. Dumanski +27 more
TL;DR: Age-related accumulation of copy-number variation in the nuclear genomes in vivo and frequency changes for both megabase- and kilobase-range variants are described and recurrent rearrangements uncovered here are candidates for common age-related defects in human blood cells.
Journal ArticleDOI
The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.
Piotr Przanowski,Michal Dabrowski,Aleksandra Ellert-Miklaszewska,Michal Kloss,Jakub Mieczkowski,Beata Kaza,Anna Ronowicz,Feng Hu,Arkadiusz Piotrowski,Helmut Kettenmann,Jan Komorowski,Jan Komorowski,Bozena Kaminska +12 more
TL;DR: The genomic distribution of Stat binding sites and the role of Stats in the gene expression in lipopolysaccharide-activated primary microglial cultures are investigated and novel direct transcriptional targets of Stat1 and Stat3 are defined and highlighted their contribution to inflammatory gene expression.