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Andrzej Poplawski
Researcher at University of Alabama at Birmingham
Publications - 19
Citations - 1584
Andrzej Poplawski is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Sulfolobus & Sulfolobus acidocaldarius. The author has an hindex of 14, co-authored 19 publications receiving 1488 citations. Previous affiliations of Andrzej Poplawski include Stockholm University & University of Maryland Biotechnology Institute.
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Journal ArticleDOI
Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy-Number-Variation Profiles
Carl E.G. Bruder,Arkadiusz Piotrowski,Antoinet C.J. Gijsbers,Robin Andersson,Stephen W. Erickson,Teresita Díaz de Ståhl,Uwe Menzel,Johanna Sandgren,Desiree von Tell,Andrzej Poplawski,Michael J. Crowley,Chiquito J. Crasto,E. Christopher Partridge,Hemant K. Tiwari,David B. Allison,Jan Komorowski,Gert-Jan B. van Ommen,Dorret I. Boomsma,Nancy L. Pedersen,Johan T. den Dunnen,Karin Wirdefeldt,Jan P. Dumanski,Jan P. Dumanski +22 more
TL;DR: It is suggested that CNV analysis in phenotypically discordant monozygotic twins may provide a powerful tool for identifying disease-predisposition loci and that caution should be exercised when interpreting disease causality of de novo CNVs found in patients based on analysis of a single tissue in routine disease-related DNA diagnostics.
Journal ArticleDOI
Somatic mosaicism for copy number variation in differentiated human tissues.
Arkadiusz Piotrowski,Arkadiusz Piotrowski,Carl E.G. Bruder,Robin Andersson,Teresita Díaz de Ståhl,Uwe Menzel,Johanna Sandgren,Andrzej Poplawski,Desiree von Tell,Chiquito J. Crasto,Adam Bogdan,Rafal Bartoszewski,Zsuzsa Bebok,Maciej Krzyżanowski,Zbigniew Jankowski,E. Christopher Partridge,Jan Komorowski,Jan P. Dumanski,Jan P. Dumanski +18 more
TL;DR: The results indicate that humans are commonly affected by somatic mosaicism for stochastic CNVs, which occur in a substantial fraction of cells, and biobanks should consider sampling multiple tissues to better address mosaicism in the studies of somatic disorders.
Journal ArticleDOI
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas
Arkadiusz Piotrowski,Arkadiusz Piotrowski,Jing Xie,Ying F Liu,Andrzej Poplawski,Alicia Gomes,Piotr Madanecki,Chuanhua Fu,Michael R. Crowley,David K. Crossman,Linlea Armstrong,Dusica Babovic-Vuksanovic,Amanda L. Bergner,Jaishri O. Blakeley,Andrea L Blumenthal,Molly S. Daniels,Howard Feit,Kathy Gardner,Stephanie Hurst,Christine Kobelka,Chung Lee,Rebecca Nagy,Katherine A. Rauen,John M. Slopis,Pim Suwannarat,Judith A. Westman,Andrea Zanko,Bruce R. Korf,Ludwine Messiaen +28 more
TL;DR: The findings identify LZTR1 as a gene predisposing to an autosomal dominant inherited disorder of multiple schwannomas in ∼80% of 22q-relatedSchwannomatosis cases lacking mutation in SMARCB1.
Journal ArticleDOI
The Methanobacterium thermoautotrophicum MCM protein can form heptameric rings
Xiong Yu,Margaret S. VanLoock,Andrzej Poplawski,Zvi Kelman,Tao Xiang,Bik Kwoon Tye,Edward H. Egelman +6 more
TL;DR: It is shown that mtMCM can assemble into a heptameric ring, which is very similar to that of hexameric replicative helicases such as bacteriophage T7 gp4, and shows that such ring structures may not be constrained to have only six subunits.
Journal ArticleDOI
Cell cycle characteristics of thermophilic archaea.
Rolf Bernander,Andrzej Poplawski +1 more
TL;DR: The in vivo organization of the chromosome DNA appeared to be different from that of eubacteria, as revealed by variation in the relative binding efficiency of different DNA stains.