Chronic hepatitis C virus infection in childhood: clinical patterns and evolution in 224 white children.
Paloma Jara,Massimo Resti,Loreto Hierro,Raffaella Giacchino,Cristiana Barbera,Lucia Zancan,Carlo Crivellaro,Etienne Sokal,Chiara Azzari,Maria Guido,Flavia Bortolotti +10 more
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TLDR
Pediatric HCV infection is usually mild, but few patients, especially those who are perinatally infected, clear viremia in the medium-term follow-up, and the higher rates of fibrosis observed in older patients suggest the possibility of an insidious progression of HCV-associated liver disease.Abstract:
The characteristics and evolution of hepatitis C virus (HCV) infection were retrospectively investigated in a study of 224 HCV RNA-seropositive white children who were consecutively recruited at 7 European centers in 1980-1998. At presentation, all patients were positive for antibodies to hepatitis C virus, 87% were asymptomatic, and 48% had alanine aminotransferase (ALT) levels that were or =15 years of age (range, 0-6 years; P<.01). Pediatric HCV infection is usually mild, but few patients, especially those who are perinatally infected, clear viremia in the medium-term follow-up. Conversely, the higher rates of fibrosis observed in older patients suggest the possibility of an insidious progression of HCV-associated liver disease.read more
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Diagnosis, management, and treatment of hepatitis C: An update
TL;DR: This document has been approved by the AASLD, the Infectious Diseases Society of America, and the American College of Gastroenterology.
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Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection
Marc G. Ghany,Timothy R. Morgan +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) initiated the hepatitis C virus guidance project (hereafter HCV guidance) in 2013 and disseminates up-to-date, peer-reviewed, unbiased, evidence-based recommendations to aid clinicians making decisions regarding the testing, management, and treatment of HCV infection.
Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children: Recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the American Academy of Pediatrics
Lynne M. Mofenson,Michael T. Brady,Susie P Danner,Kenneth L. Dominguez,Rohan Hazra,Edward Handelsman,Peter L. Havens,Steve Nesheim,Jennifer S. Read,Leslie Serchuck,Russell B. Van Dyke +10 more
TL;DR: This report updates and combines into one document earlier versions of guidelines for preventing and treating opportunistic infections (OIs) among HIV-exposed and HIV-infected children, last published in 2002 and 2004.
Journal ArticleDOI
Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease
Flavia Bortolotti,Gabriella Verucchi,Calogero Cammà,Giuseppe Cabibbo,Lucia Zancan,Giuseppe Indolfi,Raffaella Giacchino,Matilde Marcellini,Maria Grazia Marazzi,Cristiana Barbera,Giuseppe Maggiore,Pietro Vajro,S. Bartolacci,Fiorella Balli,Anna Maccabruni,Maria Guido +15 more
TL;DR: Over the course of a decade, few children with chronic HCV infection cleared viremia spontaneously, and those who did were more likely to have genotype 3, leading to end-stage liver disease in a small subgroup characterized by perinatal exposure, maternal drug use, and infection with HCV genotype 1a.
Journal ArticleDOI
Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C
Stefan Wirth,Heidrun Pieper-Boustani,Thomas Lang,Antje Ballauff,Ulrike Kullmer,Patrick Gerner,Philip Wintermeyer,Andreas Jenke +7 more
TL;DR: Combination treatment of peginterferon alfa‐2b with ribavirin showed encouraging results and was well tolerated in children and adolescents with chronic hepatitis C.
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