Journal ArticleDOI
Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease
Flavia Bortolotti,Gabriella Verucchi,Calogero Cammà,Giuseppe Cabibbo,Lucia Zancan,Giuseppe Indolfi,Raffaella Giacchino,Matilde Marcellini,Maria Grazia Marazzi,Cristiana Barbera,Giuseppe Maggiore,Pietro Vajro,S. Bartolacci,Fiorella Balli,Anna Maccabruni,Maria Guido +15 more
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TLDR
Over the course of a decade, few children with chronic HCV infection cleared viremia spontaneously, and those who did were more likely to have genotype 3, leading to end-stage liver disease in a small subgroup characterized by perinatal exposure, maternal drug use, and infection with HCV genotype 1a.About:
This article is published in Gastroenterology.The article was published on 2008-06-01. It has received 243 citations till now. The article focuses on the topics: Hepatitis C & Viral load.read more
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Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases–Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection
Marc G. Ghany,Timothy R. Morgan +1 more
TL;DR: The American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) initiated the hepatitis C virus guidance project (hereafter HCV guidance) in 2013 and disseminates up-to-date, peer-reviewed, unbiased, evidence-based recommendations to aid clinicians making decisions regarding the testing, management, and treatment of HCV infection.
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Critical review of clinical trials of bone marrow stem cells in liver disease.
TL;DR: This review critically appraise the 11 published clinical studies of bone marrow stem cells in liver disease, and focuses on the unresolved issues regarding their role.
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Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes.
TL;DR: The disruption of autophagy machinery in HCV‐infected hepatocytes activates the interferon signaling pathway and induces apoptosis, and these results suggest thatHCV‐induced Autophagy impairs the innate immune response.
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NASPGHAN Practice Guidelines: Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents
Cara L. Mack,Regino P. Gonzalez-Peralta,Nitika A. Gupta,Daniel Leung,Michael R. Narkewicz,Eve A. Roberts,Philip J. Rosenthal,Kathleen B. Schwarz +7 more
TL;DR: The guideline details the epidemiology and natural history of HCV infection in children, the diagnostic workup, monitoring and treatment of disease, and provides an update on future treatment options and areas of research.
References
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Journal ArticleDOI
Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
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Epidemiology of hepatitis C
TL;DR: Although the incidence of acute hepatitis C has declined, there is a large reservoir of chronically infected Americans who can serve as a source of transmission to others and who are at risk of the severe consequences of chronic liver disease.
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Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood-donor screening.
Manfred Vogt,Thomas Lang,Gert Frösner,Christiane Klingler,Anna F. Sendl,Anita Zeller,Baldur Wiebecke,Barbara Langer,Hans Meisner,John Hess +9 more
TL;DR: Study of 458 children who underwent cardiac surgery in Munich, Germany, before 1991, when blood-donor screening for hepatitis C was introduced in Germany found that at a mean interval of 19.8 years after the first operation, 37 of the 67 patients who were positive for anti-HCV had detectable HCV RNA in their blood.