Raffaella Romano

TL;DR: The results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways that are associated with greater activity of striatum and prefrontal cortex measured with fMRI and with reduced performance in working memory and attentional control tasks in healthy humans.

TL;DR: The relationship of methylation of the COMT Val158 allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity.

TL;DR: It is suggested that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia, and critical functional differences in the regions ofDMN are suggested.

TL;DR: The results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density.

TL;DR: Investigation of the association of DRD2 rs1076560 genotype with personality traits of emotional stability and with brain physiology during processing of emotionally relevant stimuli suggests genetically determined D2 signaling may explain part of personality traits related to emotion processing and individual variability in specific brain responses to emotionally relevant inputs.