L
Luisa Iacovelli
Researcher at Sapienza University of Rome
Publications - 61
Citations - 3029
Luisa Iacovelli is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Metabotropic glutamate receptor & Receptor. The author has an hindex of 31, co-authored 59 publications receiving 2808 citations. Previous affiliations of Luisa Iacovelli include University of Bari & Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications
TL;DR: Evidence to show that PKA and PKC can modify the functional state of the G protein-coupled receptor kinases/arrestin homologous desensitization machinery is discussed, providing a novel level of cross-talk in signal transduction.
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Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity
Gianluca Ursini,Valentina Bollati,Leonardo Fazio,Annamaria Porcelli,Luisa Iacovelli,Assia Catalani,Lorenzo Sinibaldi,Barbara Gelao,Raffaella Romano,Antonio Rampino,Paolo Taurisano,Marina Mancini,Annabella Di Giorgio,Annabella Di Giorgio,Teresa Popolizio,Andrea A. Baccarelli,Andrea A. Baccarelli,Antonio De Blasi,Giuseppe Blasi,Alessandro Bertolino,Alessandro Bertolino +20 more
TL;DR: The relationship of methylation of the COMT Val158 allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity.
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The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?
Andrea Caricasole,Agata Copani,Alessandra Caruso,Filippo Caraci,Luisa Iacovelli,Maria Angela Sortino,Georg C. Terstappen,Ferdinando Nicoletti +7 more
TL;DR: It is proposed that drugs that both inhibit the cell cycle and rescue Wnt activity could provide novel AD therapeutics and that betaAP-mediated facilitation of mitogenic Wnt signaling activates unscheduled mitosis in differentiated neurons.
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Functional characterization of WNT7A signaling in PC12 cells: Interaction with a FZD5-LRP6 receptor complex and modulation by dickkopf proteins
Andrea Caricasole,Teresa Ferraro,Luisa Iacovelli,E. Barletta,Alessandra Caruso,Daniela Melchiorri,Georg C. Terstappen,Ferdinando Nicoletti +7 more
TL;DR: It is found that PC12 cells are capable of responding to WNT7A as measured by increased β-catenin stability and activation of a T-cell factor-based luciferase reporter construct and that these cells express three members of the Frizzled family (Frizzled-2, -5, and -7) and LRP6.
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Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq.
TL;DR: It is concluded that GRK2, besides desensitizing the GPCR by phosphorylation, is able to selectively bind to Galphaq and to regulate its signaling.