L
Leonardo Fazio
Researcher at University of Bari
Publications - 78
Citations - 2873
Leonardo Fazio is an academic researcher from University of Bari. The author has contributed to research in topics: Prefrontal cortex & Working memory. The author has an hindex of 27, co-authored 71 publications receiving 2617 citations. Previous affiliations of Leonardo Fazio include Casa Sollievo della Sofferenza & Istituto Italiano di Tecnologia.
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Journal ArticleDOI
Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
Ying Zhang,Alessandro Bertolino,Leonardo Fazio,Giuseppe Blasi,Antonio Rampino,Raffaella Romano,Mei-Ling Ting Lee,Tao Xiao,Audrey C. Papp,Danxin Wang,Wolfgang Sadee +10 more
TL;DR: The results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways that are associated with greater activity of striatum and prefrontal cortex measured with fMRI and with reduced performance in working memory and attentional control tasks in healthy humans.
Journal ArticleDOI
Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity
Gianluca Ursini,Valentina Bollati,Leonardo Fazio,Annamaria Porcelli,Luisa Iacovelli,Assia Catalani,Lorenzo Sinibaldi,Barbara Gelao,Raffaella Romano,Antonio Rampino,Paolo Taurisano,Marina Mancini,Annabella Di Giorgio,Annabella Di Giorgio,Teresa Popolizio,Andrea A. Baccarelli,Andrea A. Baccarelli,Antonio De Blasi,Giuseppe Blasi,Alessandro Bertolino,Alessandro Bertolino +20 more
TL;DR: The relationship of methylation of the COMT Val158 allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity.
Journal ArticleDOI
Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia.
Fabio Sambataro,Giuseppe Blasi,Leonardo Fazio,Grazia Caforio,Paolo Taurisano,Raffaella Romano,Annabella Di Giorgio,Barbara Gelao,Luciana Lo Bianco,Apostolos Papazacharias,Teresa Popolizio,Marcello Nardini,Alessandro Bertolino,Alessandro Bertolino +13 more
TL;DR: It is suggested that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia, and critical functional differences in the regions ofDMN are suggested.
Journal ArticleDOI
Prefrontal-Hippocampal Coupling During Memory Processing Is Modulated by COMT Val158Met Genotype
Alessandro Bertolino,Alessandro Bertolino,Alessandro Bertolino,Valeria Rubino,Fabio Sambataro,Fabio Sambataro,Giuseppe Blasi,Valeria Latorre,Leonardo Fazio,Grazia Caforio,Vittoria Petruzzella,Bhaskar Kolachana,Ahmad R. Hariri,Andreas Meyer-Lindenberg,Marcello Nardini,Daniel R. Weinberger,Tommaso Scarabino +16 more
TL;DR: These results shed new light onindividual differences in responsivity and connectivity between HF and VLPFC related to genetic modulation of dopamine, a mechanism accounting at least in part for individual differences in recognition memory performance.
Journal ArticleDOI
Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.
Alessandro Bertolino,Leonardo Fazio,Grazia Caforio,Giuseppe Blasi,Antonio Rampino,Raffaella Romano,Annabella Di Giorgio,Paolo Taurisano,Audrey C. Papp,Julia K. Pinsonneault,Danxin Wang,Marcello Nardini,Teresa Popolizio,Wolfgang Sadee +13 more
TL;DR: The results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density.