Antonio Rampino

TL;DR: In this article , a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals was conducted, and the authors reported common variant associations at 287 distinct genomic loci.

TL;DR: The results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways that are associated with greater activity of striatum and prefrontal cortex measured with fMRI and with reduced performance in working memory and attentional control tasks in healthy humans.

TL;DR: It is shown that the COMT Met158 allele and the DAT 3′ variable number of tandem repeat 10-repeat allele are independently associated with more focused neuronal activity in the working memory cortical network, including the prefrontal cortex.

TL;DR: The relationship of methylation of the COMT Val158 allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity.

TL;DR: Investigation of the association of DRD2 rs1076560 genotype with personality traits of emotional stability and with brain physiology during processing of emotionally relevant stimuli suggests genetically determined D2 signaling may explain part of personality traits related to emotion processing and individual variability in specific brain responses to emotionally relevant inputs.