R
Raghu Raj Singh Thakur
Researcher at Queen's University Belfast
Publications - 6
Citations - 228
Raghu Raj Singh Thakur is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Drug delivery & Bilayer. The author has an hindex of 3, co-authored 6 publications receiving 55 citations.
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Journal ArticleDOI
Microneedle array systems for long-acting drug delivery
Lalitkumar K. Vora,Kurtis Moffatt,Ismaiel Tekko,Alejandro Javier Paredes,Fabiana Volpe-Zanutto,Deepakkumar Mishra,Ke Peng,Raghu Raj Singh Thakur,Ryan F. Donnelly +8 more
TL;DR: This review covered the different types of MNs loaded with different nano/biotherapeutics for long-acting delivery for a wide range of potential clinical applications and outlined the future development scenario of such long- acting MN delivery systems for different disease conditions to achieve improved clinical benefit.
Journal ArticleDOI
Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.
Ismaiel Tekko,Gaoyun Chen,Juan Domínguez-Robles,Raghu Raj Singh Thakur,Iman Hamdan,Lalitkumar K. Vora,Eneko Larrañeta,James C. McElnay,Helen O. McCarthy,Madeleine Rooney,Ryan F. Donnelly +10 more
TL;DR: The integrated patch produced in this work represents a promising minimally invasive transdermal drug delivery system that can overcome the skin barrier and deliver MTX in a sustained manner, which may help in minimising or even avoiding the nausea and vomiting, associated with the conventional administration routes.
Journal ArticleDOI
Long-acting nanoparticle-loaded bilayer microneedles for protein delivery to the posterior segment of the eye
Yu Wu,Lalitkumar K. Vora,Yujing Wang,Muhammad Faris Adrianto,Ismaiel Tekko,David Waite,Ryan F. Donnelly,Raghu Raj Singh Thakur +7 more
TL;DR: In this article, a model protein, ovalbumin (OVA)-encapsulated PLGA NPs were prepared and optimized using a water-in-oil-inwater (W/O/W) double emulsion method.
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Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections
Alyaa Albadr,Alyaa Albadr,Ismaiel Tekko,Ismaiel Tekko,Lalitkumar K. Vora,Ahlam A. Ali,Garry Laverty,Ryan F. Donnelly,Raghu Raj Singh Thakur +8 more
TL;DR: In this article, the authors investigated the potential use of biodegradable poly(vinylpyrrolidone) and hyaluronic acid (HA)-based rapidly dissolving microneedles for delivery of AMP-B to treat fungal infection.
Journal ArticleDOI
Laser irradiation of ocular tissues to enhance drug delivery
TL;DR: In this paper, the P.L.A.S.® laser device was applied on excised porcine scleral and corneal tissues, which showed linear relationships between depths of laser-created micropores and laser fluences at range 8.9-444.4