Rapidly dissolving microneedle patch of amphotericin B for intracorneal fungal infections
Alyaa Albadr,Alyaa Albadr,Ismaiel Tekko,Ismaiel Tekko,Lalitkumar K. Vora,Ahlam A. Ali,Garry Laverty,Ryan F. Donnelly,Raghu Raj Singh Thakur +8 more
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TLDR
In this article, the authors investigated the potential use of biodegradable poly(vinylpyrrolidone) and hyaluronic acid (HA)-based rapidly dissolving microneedles for delivery of AMP-B to treat fungal infection.Abstract:
Chronic fungal infection of the cornea could lead to blindness if not treated properly. Topical amphotericin B (AMP-B) is considered the first treatment of choice for ocular fungal infection. However, factors related to its poor solubility and penetration through intact cornea lead to poor bioavailability. Microneedles (MNs) are emerging as a minimally invasive method to enhance ocular drug delivery. This study aims to investigate the potential use of biodegradable poly(vinylpyrrolidone) (PVP) and hyaluronic acid (HA)-based rapidly dissolving MNs for delivery of AMP-B to treat fungal infection. The data obtained illustrates PVP/HA MN arrays' reproducibility, good mechanical strength, and faster dissolution with 100% drug recovery. Multiphoton microscopic results revealed that MNs successfully penetrate the corneal tissue and enhance AMP-B permeation through corneal layers. Furthermore, PVP/HA MN arrays showed high solubility. Both PVP and HA successfully decreased AMP-B cytotoxicity when compared to free drug. More interestingly, the biocompatible MN formulations preserved the antifungal activity of AMP-B, as demonstrated by significant inhibition of fungal growth. Therefore, this study shows the feasibility of ocular delivery of the poorly soluble AMP-B using a fast-dissolving MN patch.read more
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Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications?
TL;DR: The relationship between hyaluronic acid (HA) and pathological microorganisms incite new understandings on microbial infection, tissue penetration, disease progression and lastly, potential treatments as mentioned in this paper .
Journal ArticleDOI
Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: Potential for enhanced treatment of cutaneous fungal infections.
Ke Peng,Lalitkumar K. Vora,Ismaiel Tekko,Andi Dian Permana,Juan Domínguez-Robles,Delly Ramadon,Philip Chambers,Helen O. McCarthy,Eneko Larrañeta,Ryan F. Donnelly +9 more
TL;DR: In this article, microneedle patches (DMP) were loaded with micronized particles of AmB to achieve localised and long-acting intradermal delivery of Amb for treatment of cutaneous fungal infections.
Journal ArticleDOI
Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Deepak Kulkarni,Fouad Damiri,Satish Rojekar,Mehrukh Zehravi,S. Ramproshad,Dipali M. Dhoke,Shubham Musale,Ashiya A. Mulani,Pranav Modak,Roshani Paradhi,Jyotsna Vitore,Md. Habibur Rahman,Mohammed Berrada,Prabhanjan S. Giram,Simona Cavalu +14 more
TL;DR: This review broadly discusses microneedle’s types, fabrication methods, composition, characterization, applications, recent advancements, and global intellectual scenarios.
Journal ArticleDOI
Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer.
Heba M. Abd-El-Azim,Ismaiel Tekko,Ahlam A. Ali,Alyaa A. Ramadan,Noha Nafee,Nawal M. Khalafallah,Taifur Rahman,William K. McDaid,Rania G. Aly,Lalitkumar K. Vora,Steven J. Bell,Fiona Furlong,Helen O. McCarthy,Ryan F. Donnelly +13 more
TL;DR: In this paper , the first-time encapsulation of Hypericin into lipid nanocapsules (Hy-LNCs) was reported, and then application of an AdminPen™ hollow microneedles (Ho-MNs) array and an in-house fabricated Ho-MN to enable efficient intradermal delivery.
Journal ArticleDOI
Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye
TL;DR: In this paper, the authors demonstrate the effectiveness of microneedle scleral patch in delivering the model molecule, triamcinolone acetonide, to the posterior segment of the eye.
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