M
Magali Soumillon
Researcher at Broad Institute
Publications - 33
Citations - 4769
Magali Soumillon is an academic researcher from Broad Institute. The author has contributed to research in topics: Embryonic stem cell & Gene. The author has an hindex of 17, co-authored 33 publications receiving 3975 citations. Previous affiliations of Magali Soumillon include Massachusetts Institute of Technology & University of Lausanne.
Papers
More filters
Journal ArticleDOI
The evolution of gene expression levels in mammalian organs
David Brawand,Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Philippe Julien,Philippe Julien,Gábor Csárdi,Gábor Csárdi,Patrick Harrigan,Manuela Weier,Angélica Liechti,Ayinuer Aximu-Petri,Martin Kircher,Frank W. Albert,Ulrich Zeller,Philipp Khaitovich,Frank Grützner,Sven Bergmann,Sven Bergmann,Rasmus Nielsen,Rasmus Nielsen,Svante Pääbo,Henrik Kaessmann +23 more
TL;DR: It is shown that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation.
Journal ArticleDOI
The evolution of lncRNA repertoires and expression patterns in tetrapods
Anamaria Necsulea,Magali Soumillon,Maria Warnefors,Angélica Liechti,Tasman Daish,Ulrich Zeller,Julie C. Baker,Frank Grützner,Henrik Kaessmann +8 more
TL;DR: It is found that lncRNAs, in particular ancient ones, are in general actively regulated and may function predominantly in embryonic development, and an evolutionarily conserved co-expression network is reconstructed.
Journal ArticleDOI
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract
Melis N. Anahtar,Melis N. Anahtar,Elizabeth H. Byrne,Kathleen E. Doherty,Brittany A. Bowman,Hidemi S. Yamamoto,Magali Soumillon,Nikita Padavattan,Nasreen Ismail,Amber Moodley,Mary E. Sabatini,Musie Ghebremichael,Chad Nusbaum,Curtis Huttenhower,Herbert W. Virgin,Thumbi Ndung'u,Thumbi Ndung'u,Krista L. Dong,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Raina N. Fichorova,Douglas S. Kwon,Douglas S. Kwon +23 more
TL;DR: This study proposes a mechanism by which cervicovaginal microbiota impact genital inflammation and thereby might affect a woman's reproductive health, including her risk of acquiring HIV.
Journal ArticleDOI
Cellular Source and Mechanisms of High Transcriptome Complexity in the Mammalian Testis
Magali Soumillon,Magali Soumillon,Anamaria Necsulea,Anamaria Necsulea,Manuela Weier,David Brawand,David Brawand,Xiaolan Zhang,Hongcang Gu,Pauline Barthès,Maria Kokkinaki,Serge Nef,Andreas Gnirke,Martin Dym,Bernard de Massy,Tarjei S. Mikkelsen,Tarjei S. Mikkelsen,Henrik Kaessmann,Henrik Kaessmann +18 more
TL;DR: It is shown that transcription of the genome is substantially more widespread in the testis than in other organs across representative mammals, and it is revealed that meiotic spermatocytes and especially postmeiotic round sperMatids have remarkably diverse transcriptomes, which explains the high transcriptome complexity of the testes as a whole.
Journal ArticleDOI
Birth and expression evolution of mammalian microRNA genes
Julien Meunier,Julien Meunier,Frédéric Lemoine,Magali Soumillon,Magali Soumillon,Angélica Liechti,Manuela Weier,Katerina Guschanski,Katerina Guschanski,Haiyang Hu,Philipp Khaitovich,Henrik Kaessmann,Henrik Kaessmann +12 more
TL;DR: The study provides detailed insights into the birth and evolution of mammalian miRNA genes and the associated selective forces, and suggests a high rate of miRNA family turnover in mammals with many newly emerged miRNA families being lost soon after their formation.