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Rainer Breitling

Researcher at University of Manchester

Publications -  239
Citations -  21369

Rainer Breitling is an academic researcher from University of Manchester. The author has contributed to research in topics: Synthetic biology & Metabolomics. The author has an hindex of 65, co-authored 233 publications receiving 19231 citations. Previous affiliations of Rainer Breitling include University of Glasgow & University of Groningen.

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Journal ArticleDOI

Efficient learning in metabolic pathway designs through optimal assembling

Pablo Carbonell, +3 more
- 01 Jan 2019 - 
TL;DR: The Pareto surface spanned by the optimal experimental design space of combinatorial libraries that are found in a large-scale diverse set of genetic circuits and plasmid vectors are explored, suggesting optimal synthetic biology design approaches for biomanufacturing pipelines.
Journal ArticleDOI

Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.

Brigitte Keller, +8 more
- 27 Mar 2006 - 
TL;DR: By sequencing the gene from a diverse set of related species, it is shown that this duplication is of very recent evolutionary origin, having occurred in the common ancestor of Hominoidae (apes and humans) while being absent in the closely related Old World monkeys and the outgroup species Tupaia belangeri and Mus musculus.
Journal ArticleDOI

Towards engineering and production of artificial spider silk using tools of synthetic biology

Hashwardhan Poddar, +2 more
TL;DR: This review aims to highlight the recent progress that has been made in the study of spider Silk proteins using different branches of synthetic biology and discusses the different computational approaches, directed evolution techniques and various expression platforms that have been tested for the successful production of spider silk.
Posted ContentDOI

The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers

William Finnigan, +5 more
- 13 Feb 2020 - 
TL;DR: It is suggested that the inclusion of the terminal domains is needed to match the response to shear that native spidroins exhibit, and a pH drop alone is insufficient to trigger assembly in a wet-spinning process, and must be combined with salting-out for effective fiber formation.
Book ChapterDOI

The Silicon Trypanosome: A Test Case of Iterative Model Extension in Systems Biology

Fiona Achcar, +16 more
- 01 Jan 2014 - 
TL;DR: The Silicon Trypanosome project as mentioned in this paper is a project that brings together modellers and experimentalists to improve and extend this core model with new pathways and additional levels of regulation, which can now be used for a wide range of different studies in systems biology.