R
Rainer Breitling
Researcher at University of Manchester
Publications - 239
Citations - 21369
Rainer Breitling is an academic researcher from University of Manchester. The author has contributed to research in topics: Synthetic biology & Metabolomics. The author has an hindex of 65, co-authored 233 publications receiving 19231 citations. Previous affiliations of Rainer Breitling include University of Glasgow & University of Groningen.
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Journal ArticleDOI
Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2).
TL;DR: A strong perturbation in the expression of three pigmented antibiotic clusters in the mutant throughout the growth curve is reported, thus providing a molecular explanation for the antibiotic phenotype observed previously.
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The silicon trypanosome
Barbara M. Bakker,R. Luise Krauth-Siegel,Christine Clayton,Keith R. Matthews,Mark Girolami,Hans V. Westerhoff,Hans V. Westerhoff,Paul A.M. Michels,Paul A.M. Michels,Rainer Breitling,Michael P. Barrett +10 more
TL;DR: It is expected that, in the long run, the quantitative modelling enabled by the Silicon Trypanosome will play a key role in selecting the most suitable targets for developing new anti-parasite drugs.
Journal ArticleDOI
Mobilising ion mobility mass spectrometry for metabolomics.
Eleanor Sinclair,Katherine A. Hollywood,Cunyu Yan,Richard T. Blankley,Rainer Breitling,Perdita E. Barran +5 more
TL;DR: It is concluded that the integration of ion mobility into current LC-MS workflows can aid in small molecule identification for both targeted and untargeted metabolite screening.
Journal ArticleDOI
Robust signaling networks of the adipose secretome
TL;DR: In this article, the authors argue that a systems biology approach to understand the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment.
Journal ArticleDOI
Synthetic Biology of Natural Products
Rainer Breitling,Eriko Takano +1 more
TL;DR: The current state of the field is discussed, highlighting recent advances and remaining bottlenecks, and global genomic assessments of natural product biosynthetic capacities across large parts of microbial diversity are provided.