J
Jehnna L. Ronan
Researcher at Stanford University
Publications - 11
Citations - 2414
Jehnna L. Ronan is an academic researcher from Stanford University. The author has contributed to research in topics: Induced pluripotent stem cell & Chromatin remodeling. The author has an hindex of 10, co-authored 10 publications receiving 2239 citations. Previous affiliations of Jehnna L. Ronan include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Lena Ho,Jehnna L. Ronan,Jiang Wu,Brett T. Staahl,Lei Chen,Ann Kuo,Julie A. Lessard,Julie A. Lessard,Alexey I. Nesvizhskii,Jeff Ranish,Gerald R. Crabtree +10 more
TL;DR: It is shown that BAF complexes are required for the self-renewal and pluripotency of mouse ES cells but not for the proliferation of fibroblasts or other cells, suggesting that esBAF complexes are specialized to interact with ES cell-specific regulators, providing a potential explanation for the requirement of BAF complex in pluripOTency.
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A microengraving method for rapid selection of single cells producing antigen-specific antibodies.
J. Christopher Love,Jehnna L. Ronan,Gijsbert M. Grotenbreg,Annemarthe G. Van der Veen,Hidde L. Ploegh +4 more
TL;DR: A soft lithographic method based on intaglio printing to generate microarrays comprising the secreted products of single cells enabling a rapid and high-throughput system for identification, recovery and clonal expansion of cells producing antigen-specific antibodies.
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From neural development to cognition: unexpected roles for chromatin
TL;DR: Interestingly, mutations in EZH2 and certain BAF complex components have roles in both neurodevelopmental disorders and cancer, and overlapping point mutations are suggesting functionally important residues and domains.
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An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
TL;DR: These studies indicate that esBAF is an essential component of the core pluripotency transcriptional network, and might also be a critical component in the LIF and BMP signaling pathways essential for maintenance of self-renewal and pluripOTency.
Journal ArticleDOI
esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
TL;DR: It is found that STAT3 binding across the pluripotent genome is dependent on Brg1, the ATPase subunit of a specialized chromatin remodelling complex (esBAF) found in ESCs, and that esBAF does not simply antagonize PcG, but acts both antagonistically and synergistically with the common goal of supporting pluripotency.