Rajiv Narayan

TL;DR: This work shows that mitigating off-target effects is feasible in these datasets via computational methodologies to produce a consensus gene signature (CGS) and compared RNAi technology to clustered regularly interspaced short palindromic repeat (CRISPR)-based knockout by analysis of 373 single guide RNAs (sgRNAs) to show that the on-target efficacies are comparable, but CRISPR technology is far less susceptible to systematic off- target effects.

TL;DR: The existence of distinct time scales for temporal resolution and temporal integration is demonstrated and how they arise from cortical neural responses to complex dynamic sounds is explained.

TL;DR: This work uses the model system of songbirds to investigate whether neurons in field L, the homolog of primary auditory cortex, can match behavioral performance in the discrimination of conspecific songs, and uses a classification framework based on the (dis)similarity between single spike trains to quantify neural discrimination.

TL;DR: The cholesterol-lowering drug lovastatin showed anti-LSC activity in vitro and in an in vivo bone marrow transplantation model, and Mechanistic studies demonstrated that the effect was on target, via inhibition of HMG-CoA reductase.

TL;DR: This work examines neural responses in zebra finch field L to target birdsongs that were embedded in three different maskers and identifies neural interference that could explain the perceptual interference at the heart of the cocktail party problem.