R
Rajiv Narayan
Researcher at Broad Institute
Publications - 39
Citations - 6113
Rajiv Narayan is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene expression profiling & Auditory cortex. The author has an hindex of 22, co-authored 37 publications receiving 3885 citations. Previous affiliations of Rajiv Narayan include Boston University & Harvard University.
Papers
More filters
Posted ContentDOI
Open Community Challenge Reveals Molecular Network Modules with Key Roles in Diseases
Sarvenaz Choobdar,Mehmet Eren Ahsen,Jake Crawford,Mattia Tomasoni,David Lamparter,Junyuan Lin,Benjamin Hescott,Xiaozhe Hu,Johnathan Mercer,Ted Natoli,Rajiv Narayan,Aravind Subramanian,Gustavo Stolovitzky,Zoltán Kutalik,Kasper Lage,Donna K. Slonim,Julio Saez-Rodriguez,Lenore J. Cowen,Sven Bergmann,Daniel Marbach +19 more
TL;DR: It is found that most of the modules identified in the "Disease Module Identification DREAM Challenge" correspond to core disease-relevant pathways, which often comprise therapeutic targets and correctly prioritize candidate disease genes.
Posted ContentDOI
Non-oncology drugs are a source of previously unappreciated anti-cancer activity
Steven M. Corsello,Steven M. Corsello,Rohith T. Nagari,Ryan Spangler,Jordan Rossen,Mustafa Kocak,Jordan Bryan,Ranad Humeidi,David Peck,Xiaoyun Wu,Anna Tang,Vickie M. Wang,Sam Bender,Evan Lemire,Rajiv Narayan,Philip Montgomery,Uri Ben-David,Yii-Der Ida Chen,Matthew G. Rees,Nicholas J. Lyons,James M. McFarland,Bang Wong,Li Wang,Nancy Dumont,Patrick O'Hearn,Eric Stefan,John G. Doench,Heidi Greulich,Matthew Meyerson,Matthew Meyerson,Francisca Vazquez,Ayshwarya Subramanian,Jennifer Roth,Joshua Bittker,Jesse S. Boehm,Christopher C. Mader,Aviad Tsherniak,Todd R. Golub +37 more
TL;DR: The results illustrate the potential of the PRISM drug repurposing resource as a starting point for new oncology therapeutic development and relative barcode abundance following treatment thus reflects cell line viability.
Journal ArticleDOI
Delayed inhibition in cortical receptive fields and the discrimination of complex stimuli.
TL;DR: It is found that single model neurons with delayed inhibitory STRFs can discriminate accurately between songs, and the presence of the inhibitory subregion can improve discrimination.
Journal ArticleDOI
Spatial Unmasking of Birdsong in Zebra Finches (Taeniopygia guttata) and Budgerigars (Melopsittacus undulatus)
Micheal L. Dent,Elizabeth M. McClaine,Virginia Best,Erol J. Ozmeral,Rajiv Narayan,Frederick J. Gallun,Kamal Sen,Barbara G. Shinn-Cunningham +7 more
TL;DR: The results suggest that spatial factors are important for birds in the identification of natural signals in noisy environments.
Posted ContentDOI
Assessment of network module identification across complex diseases
Sarvenaz Choobdar,Mehmet Eren Ahsen,Jake Crawford,Mattia Tomasoni,Tao Fang,David Lamparter,Junyuan Lin,Benjamin Hescott,Xiaozhe Hu,Johnathan Mercer,Ted Natoli,Rajiv Narayan,Aravind Subramanian,Jitao D. Zhang,Gustavo Stolovitzky,Zoltán Kutalik,Kasper Lage,Donna K. Slonim,Julio Saez-Rodriguez,Lenore J. Cowen,Sven Bergmann,Daniel Marbach +21 more
TL;DR: A critical assessment of 75 contributed module identification methods reveals novel top-performing algorithms, which recover complementary trait-associated modules that correspond to core disease-relevant pathways.