R
Ramachandran Ramalingam
Researcher at Cornell University
Publications - 8
Citations - 399
Ramachandran Ramalingam is an academic researcher from Cornell University. The author has contributed to research in topics: Growth factor & Gene. The author has an hindex of 6, co-authored 8 publications receiving 394 citations. Previous affiliations of Ramachandran Ramalingam include NewYork–Presbyterian Hospital.
Papers
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Journal ArticleDOI
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus
Ben-Gary Harvey,Philip L. Leopold,Neil R. Hackett,T M Grasso,P M Williams,A L Tucker,Robert J. Kaner,Barbara Ferris,I Gonda,T D Sweeney,Ramachandran Ramalingam,Imre Kovesdi,Steven Shak,Ronald G. Crystal +13 more
TL;DR: The data demonstrate that an Ad vector can deliver sufficient levels of CFTR cDNA to the airway epithelium so that CFTR expression protects the lungs from the respiratory manifestations of CF, and further repetitive administration does not lead to repetitive expression.
Journal ArticleDOI
Upregulation of transcription factors in lung in the early phase of postpneumonectomy lung growth.
Leonard J. Landesberg,Ramachandran Ramalingam,Kenneth Lee,Todd K. Rosengart,Ronald G. Crystal +4 more
TL;DR: Data support the concept that transcription factors function early in the cascade of events leading to the compensatory response, and time-course analysis over the first 24 h confirmed the transient nature of the early upregulation.
Journal ArticleDOI
E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells.
TL;DR: Evaluation of E1−E4+ Ad vectors showed that the antiapoptoic signal requires the presence of E4 genes in the vector genome, suggesting that one or more E4 open reading frames of subgroup C Ad initiate a “pro-life” program that modifies cultured endothelial cells to survive for prolonged periods.
Journal ArticleDOI
Induction of Endogenous Genes following Infection of Human Endothelial Cells with an E1− E4+Adenovirus Gene Transfer Vector
TL;DR: Interestingly, additional deletion of the E4 gene obviated the upregulation of genes in endothelial cells by the E1− E3− Ad vector, suggesting that genes carried by theE4 region play a central role in modifying target cell gene expression.
Patent
Endothelial cell culture
TL;DR: The in vitro models used to define microvascular endothelial cells and the properties of microvessel endothelium from human breast adipose tissue showed striking similarities to those used in the real world, where microvessels are found in connective tissue of the immune system and the brain.