Ramanuj DasGupta

TL;DR: It is reported that this pathway operates in keratinocytes and that mice expressing a stabilized beta-catenin controlled by an epidermal promoter undergo a process resembling de novo hair morphogenesis, suggesting that transient beta-Catenin stabilization may be a key player in the long-sought epidersmal signal leading to hair development and implicate aberrant beta- catenin activation in hair tumors.

TL;DR: It is demonstrated that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation, revealing the existence of positive and negative regulators of these factors in the skin and unveiling the importance of activated LEF/ TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place.

TL;DR: An intricate molecular programme is revealed that links two extracellular signalling pathways to the formation of a nuclear transcription factor that acts on target genes to remodel cellular junctions and permit follicle formation.

TL;DR: Findings provide powerful evidence that the status of Tcf3/Lef complexes has a key role in controlling cell fate lineages in multipotent skin stem cells.

TL;DR: It is shown that depletion of class A genes redistributes Golgi membranes into the endoplasmic reticulum, depletion of classes B, C, and D genes leads to Golgi fragmentation, and depletion ofclass D genes causes no obvious change.