Uri Gat

TL;DR: It is reported that this pathway operates in keratinocytes and that mice expressing a stabilized beta-catenin controlled by an epidermal promoter undergo a process resembling de novo hair morphogenesis, suggesting that transient beta-Catenin stabilization may be a key player in the long-sought epidersmal signal leading to hair development and implicate aberrant beta- catenin activation in hair tumors.

TL;DR: The cell origin and aetiology of human pilomatricomas is explored, and nuclear LEF-1 in the dividing tumour cells is found, providing biochemical evidence that pilom atricomas are derived from hair matrix cells.

TL;DR: Findings provide powerful evidence that the status of Tcf3/Lef complexes has a key role in controlling cell fate lineages in multipotent skin stem cells.

TL;DR: It is found that Runx3 expression overlapped with that of Runx1 in the hematopoietic system, whereas in sensory ganglia, epidermal appendages, and developing skeletal elements, their expression was confined to different compartments, supporting the possibility that cross-regulation between them plays a role in embryogenesis.

TL;DR: These findings shed new light on the structural components of spider dragline silk, allowing further elucidation of their assembly properties, which may open the door for commercial applications.