R
Ramesh Rathi
Researcher at Harvard University
Publications - 21
Citations - 1531
Ramesh Rathi is an academic researcher from Harvard University. The author has contributed to research in topics: Polyethylene glycol & Polymer. The author has an hindex of 10, co-authored 20 publications receiving 1485 citations. Previous affiliations of Ramesh Rathi include University of Utah.
Papers
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Journal ArticleDOI
Biodegradable block copolymers for delivery of proteins and water-insoluble drugs
Gaylen M. Zentner,Ramesh Rathi,Chung Shih,James C. McRea,Min Hyo Seo,Hunseung Oh,B. G. Rhee,Jiri Mestecky,Zina Moldoveanu,Michael H. Morgan,Steven D. Weitman +10 more
TL;DR: ReGel's inherent ability to solubilize (400 to >2000-fold) and stabilize poorly soluble and sensitive drugs, including proteins is a substantial benefit and the gel provided excellent control of the release of paclitaxel for approximately 50 days.
Patent
Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
TL;DR: A block copolymer made of a major amount of hydrophobic poly(lactide-co-glycolide) copolymers and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall average molecular weight of between about 3100 and 4500, possesses reverse thermal gelation properties.
Journal ArticleDOI
Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres.
TL;DR: The sustained drug release profile and cellular internalization results suggest that nanospheres loaded with paclitaxel may potentially be used as an endocytizable, local sustained drug delivery system for the prevention of restenosis.
Journal ArticleDOI
EUS-guided injection of paclitaxel (OncoGel) provides therapeutic drug concentrations in the porcine pancreas (with video).
Kai Matthes,Mari Mino-Kenudson,Dushyant V. Sahani,Nagaraj S. Holalkere,Kirk D. Fowers,Ramesh Rathi,William R. Brugge +6 more
TL;DR: The EUS-guided injection of OncoGel into the pancreas of the pig provided high and sustained localized concentrations of paclitaxel, and this technique is a potential minimally invasive local treatment option for unresectable pancreatic tumors.
Journal ArticleDOI
Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel
Takahisa Masaki,Ramesh Rathi,Gaylen M. Zentner,John K. Leypoldt,Syed F. Mohammad,Gregory L. Burns,Li Li,Sergey B. Zhuplatov,Thanit Chirananthavat,Seung-Jung Kim,Steven E. Kern,John Holman,Sung Wan Kim,Alfred K. Cheung +13 more
TL;DR: The results suggest that the local delivery of antiproliferative agents using a thermosensitive, injectable biodegradable copolymer (ReGel) for sustained delivery is a promising strategy to inhibit neointimal hyperplasia of arteriovenous hemodialysis grafts.