G
Gaylen M. Zentner
Researcher at Myriad Genetics
Publications - 20
Citations - 1897
Gaylen M. Zentner is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Polyethylene glycol & Polymer. The author has an hindex of 9, co-authored 20 publications receiving 1717 citations. Previous affiliations of Gaylen M. Zentner include State Street Corporation.
Papers
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Journal ArticleDOI
Biodegradable block copolymers for delivery of proteins and water-insoluble drugs
Gaylen M. Zentner,Ramesh Rathi,Chung Shih,James C. McRea,Min Hyo Seo,Hunseung Oh,B. G. Rhee,Jiri Mestecky,Zina Moldoveanu,Michael H. Morgan,Steven D. Weitman +10 more
TL;DR: ReGel's inherent ability to solubilize (400 to >2000-fold) and stabilize poorly soluble and sensitive drugs, including proteins is a substantial benefit and the gel provided excellent control of the release of paclitaxel for approximately 50 days.
Patent
Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
TL;DR: A block copolymer made of a major amount of hydrophobic poly(lactide-co-glycolide) copolymers and a minor amount of a hydrophilic polyethylene glycol polymer B-block, having an overall average molecular weight of between about 3100 and 4500, possesses reverse thermal gelation properties.
Journal ArticleDOI
Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors
Nicholas A. Peppas,Ruth Duncan,Gary E. Wnek,Allan S. Hoffman,Guanghui Gao,Sung Wan Kim,Doo Sung Lee,Michael Hadjiargyrou,Elka Touitou,Denize Ainbinder,Russell J. Mumper,Alain Rolland,Takuro Niidome,Vinod Labhasetwar,Shi Liu,Guangyuan Zhou,Yubin Huang,Zhigang Xie,Xiabin Jing,Noemi Csaba,María J. Alonso,Omar Abdel-Rahman Ali,David J. Mooney,Peter Lönn,Steven F. Dowdy,Si-Shen Feng,Jinming Gao,Eun Seong Lee,Kun Na,You Han Bae,Gaylen M. Zentner,Hye Sung Kim,Hyuk Sang Yoo,Masamichi Nakayama,Teruo Okano,Zi-Xian Liao,Er Yuan Chuang,Chun-Wen Hsiao,Hsing-Wen Sung,Horacio Cabral,Kazunori Kataoka,Praful R. Nair,Dennis E. Discher,Samir Mitragotri +43 more
TL;DR: A compilation of commentaries gives a historical perspective and current status of research covered in some of the most cited research articles in the history of the Journal of Controlled Release.
Journal ArticleDOI
New biodegradable polymers for injectable drug delivery systems
TL;DR: New star-shaped block copolymers, of which the typical molecular architecture is presented, results from their distinct solution properties, thermal properties and morphology, which provide unique behavior that sol (at low temperature) form gel (at body temperature).
Journal ArticleDOI
Inhibition of neointimal hyperplasia in vascular grafts by sustained perivascular delivery of paclitaxel
Takahisa Masaki,Ramesh Rathi,Gaylen M. Zentner,John K. Leypoldt,Syed F. Mohammad,Gregory L. Burns,Li Li,Sergey B. Zhuplatov,Thanit Chirananthavat,Seung-Jung Kim,Steven E. Kern,John Holman,Sung Wan Kim,Alfred K. Cheung +13 more
TL;DR: The results suggest that the local delivery of antiproliferative agents using a thermosensitive, injectable biodegradable copolymer (ReGel) for sustained delivery is a promising strategy to inhibit neointimal hyperplasia of arteriovenous hemodialysis grafts.