R
Ramin Khatami
Researcher at University of Bern
Publications - 97
Citations - 4231
Ramin Khatami is an academic researcher from University of Bern. The author has contributed to research in topics: Narcolepsy & Polysomnography. The author has an hindex of 31, co-authored 84 publications receiving 3386 citations. Previous affiliations of Ramin Khatami include University of Zurich & Boston Children's Hospital.
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Journal ArticleDOI
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
Claudio L. Bassetti,Antoine Roger Adamantidis,Denis Burdakov,Denis Burdakov,Denis Burdakov,Fang Han,Ulf Kallweit,Ramin Khatami,Frits Koning,Brigitte R. Kornum,Gert Jan Lammers,Roland S. Liblau,Pierre H. Luppi,Pierre H. Luppi,Geert Mayer,T. Pollmacher,Takeshi Sakurai,Federica Sallusto,Federica Sallusto,Thomas E. Scammell,Mehdi Tafti,Yves Dauvilliers,Yves Dauvilliers +22 more
TL;DR: Current understanding of how genetic, environmental and immune-related factors contribute to a prominent orexin signalling deficiency in patients with NT1 are focused on, along with uncertainties concerning the ‘narcoleptic borderland’, including narcolepsy type 2 (NT2).
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A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans
Julia Retey,Martin Adam,E. Honegger,Ramin Khatami,Ulrich F O Luhmann,H. H. Jung,Wolfgang Berger,Hans-Peter Landolt +7 more
TL;DR: It is shown in humans that a genetic variant of adenosine deaminase, which is associated with the reduced metabolism ofAdenosine to inosine, specifically enhances deep sleep and slow-wave activity during sleep and SWA during sleep.
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A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep.
Julia Retey,Martin Adam,Ramin Khatami,Ulrich F O Luhmann,H. H. Jung,Wolfgang Berger,Hans-Peter Landolt +6 more
TL;DR: It is shown in humans that habitual caffeine consumption is associated with reduced sleep quality in self‐rated caffeine‐sensitive individuals, but not in caffeine‐insensitive individuals, and a common variation in ADORA2A contributes to subjective and objective responses to caffeine on sleep.
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T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Daniela Latorre,Ulf Kallweit,Eric Armentani,Mathilde Foglierini,Mathilde Foglierini,Federico Mele,Antonino Cassotta,Antonino Cassotta,Sandra Jovic,David Jarrossay,Johannes Mathis,Francesco Zellini,Burkhard Becher,Antonio Lanzavecchia,Ramin Khatami,Mauro Manconi,Mehdi Tafti,Claudio L. Bassetti,Federica Sallusto,Federica Sallusto +19 more
TL;DR: The detection of hypocretin-specific autoreactive CD4+ and CD8+ T cells in patients with narcolepsy reveals the autoimmune aetiology of this disorder and provides a basis for rapid diagnosis and treatment of this disease.
Journal ArticleDOI
Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans.
Hans-Peter Landolt,Julia Retey,Karin Tönz,Julie M. Gottselig,Ramin Khatami,Isabelle Buckelmüller,Peter Achermann +6 more
TL;DR: It is suggested that caffeine attenuated the build-up of sleep propensity associated with wakefulness, and support an important role of adenosine and adenosines receptors in the homeostatic regulation of sleep.