C
Chin-Tong Ong
Researcher at National University of Singapore
Publications - 25
Citations - 4593
Chin-Tong Ong is an academic researcher from National University of Singapore. The author has contributed to research in topics: Chromatin & CTCF. The author has an hindex of 15, co-authored 21 publications receiving 4065 citations. Previous affiliations of Chin-Tong Ong include Emory University & Institute of Molecular and Cell Biology.
Papers
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Journal ArticleDOI
Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment
Jennifer E. Phillips-Cremins,Michael E.G. Sauria,Amartya Sanyal,Tatiana I. Gerasimova,Bryan R. Lajoie,Joshua S.K. Bell,Chin-Tong Ong,Tracy A. Hookway,Changying Guo,Yuhua Sun,Michael Bland,William Wagstaff,Stephen Dalton,Todd C. McDevitt,Ranjan Sen,Job Dekker,James Taylor,Victor G. Corces +17 more
TL;DR: It is concluded that cell-type-specific chromatin organization occurs at the submegabase scale and that architectural proteins shape the genome in hierarchical length scales.
Journal ArticleDOI
CTCF: an architectural protein bridging genome topology and function
Chin-Tong Ong,Victor G. Corces +1 more
TL;DR: Although CTCF has been assigned various roles that are often contradictory, new results now help to draw a unifying model to explain the many functions of this protein.
Journal ArticleDOI
Enhancer function: new insights into the regulation of tissue-specific gene expression.
Chin-Tong Ong,Victor G. Corces +1 more
TL;DR: Surprisingly, cohesin and non-coding RNAs are emerging as crucial players responsible for facilitating enhancer–promoter interactions at some genes and may be required not only to facilitate initiation of transcription but also to activate the release of RNA polymerase II from promoter-proximal pausing.
Journal ArticleDOI
Insulator function and topological domain border strength scale with architectural protein occupancy.
Kevin Van Bortle,Michael H. Nichols,Li Li,Chin-Tong Ong,Naomi Takenaka,Zhaohui S. Qin,Victor G. Corces +6 more
TL;DR: An extensive pattern of colocalization in which architectural proteins establish dense clusters at the borders of topological domains is uncovered, identifying a spectrum of architectural protein occupancy that scales with the topological structure of chromosomes and the regulatory potential of these elements.
Journal ArticleDOI
Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing.
Li Li,Xiaowen Lyu,Chunhui Hou,Naomi Takenaka,Huy Q. Nguyen,Chin-Tong Ong,Caelin Cubeñas-Potts,Ming Hu,Elissa P. Lei,Giovanni Bosco,Zhaohui S. Qin,Victor G. Corces +11 more
TL;DR: It is shown that temperature stress induces relocalization of architectural proteins from TAD borders to inside TADs, and this is accompanied by a dramatic rearrangement in the 3D organization of the nucleus, suggesting that the TAD organization of metazoan genomes is plastic and can be reconfigured quickly.