V
Victor G. Corces
Researcher at Emory University
Publications - 222
Citations - 22271
Victor G. Corces is an academic researcher from Emory University. The author has contributed to research in topics: Chromatin & Gene. The author has an hindex of 72, co-authored 210 publications receiving 19925 citations. Previous affiliations of Victor G. Corces include University of Wyoming & Complutense University of Madrid.
Papers
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Journal ArticleDOI
CTCF: Master Weaver of the Genome
TL;DR: It is suggested that CTCF may be a heritable component of an epigenetic system regulating the interplay between DNA methylation, higher-order chromatin structure, and lineage-specific gene expression.
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Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment
Jennifer E. Phillips-Cremins,Michael E.G. Sauria,Amartya Sanyal,Tatiana I. Gerasimova,Bryan R. Lajoie,Joshua S.K. Bell,Chin-Tong Ong,Tracy A. Hookway,Changying Guo,Yuhua Sun,Michael Bland,William Wagstaff,Stephen Dalton,Todd C. McDevitt,Ranjan Sen,Job Dekker,James Taylor,Victor G. Corces +17 more
TL;DR: It is concluded that cell-type-specific chromatin organization occurs at the submegabase scale and that architectural proteins shape the genome in hierarchical length scales.
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CTCF: an architectural protein bridging genome topology and function
Chin-Tong Ong,Victor G. Corces +1 more
TL;DR: Although CTCF has been assigned various roles that are often contradictory, new results now help to draw a unifying model to explain the many functions of this protein.
Journal ArticleDOI
Enhancer function: new insights into the regulation of tissue-specific gene expression.
Chin-Tong Ong,Victor G. Corces +1 more
TL;DR: Surprisingly, cohesin and non-coding RNAs are emerging as crucial players responsible for facilitating enhancer–promoter interactions at some genes and may be required not only to facilitate initiation of transcription but also to activate the release of RNA polymerase II from promoter-proximal pausing.
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Organizational principles of 3D genome architecture
TL;DR: Observations suggest that the 3D organization of the genome is an emergent property of chromatin and its components, and thus may not be only a determinant but also a consequence of its function.