Raphaël Mourad

TL;DR: In this article, the authors show that topologically associating domains are functional units of the DNA damage response, and are instrumental for the correct establishment of γH2AX-53BP1 chromatin domains in a manner that involves one-sided cohesin-mediated loop extrusion on both sides of the DSB.

TL;DR: This review of the latent tree model, a particular type of probabilistic graphical models, deserves attention because its simple structure allows simple and efficient inference, while its latent variables capture complex relationships.

TL;DR: An accurate modeling of dependences between genetic markers is presented, based on a forest of hierarchical latent class models which is a particular class of probabilistic graphical models which offers an adapted framework to deal with the fuzzy nature of linkage disequilibrium blocks.

TL;DR: The role of a hormone - estrogen - on genome organization, and its effect on gene regulation in cancer, is revealed through genome-wide mapping of chromatin interactions (Hi-C) over the time after estrogen stimulation of breast cancer cells.

TL;DR: In this paper, the authors performed genome-wide mapping of chromatin interactions (Hi-C) over the time after estrogen stimulation of breast cancer cells, and found that gene-rich chromosomes as well as areas of open and highly transcribed chromatins are rearranged to greater spatial proximity, thus enabling genes to share transcriptional machinery and regulatory elements.